Photodamaged Skin Clinical Trial
Official title:
Comparison of the Effect of Vaseline and Bepanthen® "Wund- Und Heilsalbe" on the Wound Healing Following Fractional Ablative Laser Treatment of Photo-damaged Skin
In the field of dermatology the healing process and therefore the success of a laser treatment are strongly determined by an appropriate postoperative treatment of the laser-treated skin. The manufacturer of CO2 laser systems recommends the application of Vaseline postoperatively to protect the treated tissue from air exposition until encrustation of the laser-treated skin decreases (usually after 7-14 days). An alternative to Vaseline could be Bepanthen® "Wund- und Heilsalbe" (Bayer). It contains the active ingredient pro-vitamin Dexapanthenol, which is widely used in dermatology therapy. The product helps to stabilize the protective barrier of the skin, to reduce the skin irritation, to stimulate the skin regeneration and to promote the wound healing. In an in-vitro study Bepanthen® "Wund- und Heilsalbe" triggered wound closure significantly faster compared to Vaseline. In this study the effect of Bepanthen® "Wund- und Heilsalbe" on wound healing should be investigated and compared to Vaseline in vivo following fractional ablative CO2 laser treatment of photo-damaged skin.
The healing process and therefore the success of a laser treatment are strongly determined by
an appropriate treatment with special skin care products of the laser-treated skin. Cooling
measures prevent the swelling of the treated skin area, if applied directly after the
procedure. A soothing and wound-healing-promoting care applied subsequently for seven days,
can support and also speed up the healing process.
The Lumenis® Company is the manufacturer of CO2 laser systems and recommends the application
of the Okklusiv ointment Vaseline® postoperatively, in order to prevent the treated tissue to
the air exposition. These occlusive wound care should be maintained, until the encrustation
of the laser-treated skin decreases, which usually happens 7-14 days postoperatively.
The Bepanthen® Wund- und Heilsalbe (Bayer) could be a possible alternative to Vaseline® as
postoperative care. Bepanthen® Wund- und Heilsalbe contains pro-vitamin Dexpanthenol as an
active ingredient and is widely used in dermatological therapy. The product helps to
stabilize the protective barrier of the skin, to reduce the skin irritation, to stimulate the
skin regeneration and to promote the wound healing. The investigators examined the effect of
substances containing Dexpanthenol on wound healing process applied topically, in
three-dimensional (3D) dermal skin equivalents in vitro. For this purpose, many lesions with
standardized diameter and depth were generated using a laser. The subsequent topical
application of substances containing dexpanthenol on the wound healing models (treated with
laser) for three-days led to a significantly faster wound closure compared to
Vaseline-covered models (Marquardt et al., 2015). The aim of this study is to compare the
effect of white Vaseline with Bepanthen® "Wund- und Heilsalbe" (both applied postoperatively)
on the wound healing following fractional ablative CO2 laser treatment of photo-damaged skin
in vivo.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Terminated |
NCT03573076 -
Treatment of Photodamaged Skin of the décolleté
|
Phase 4 | |
| Suspended |
NCT03963102 -
Duration of Ameluz Application in Acral Actinic Keratoses Response
|
Phase 4 | |
| Completed |
NCT01283464 -
Comparison of Retinol 1.0% and Tretinoin 0.02% in the Treatment of Moderate to Severe Photodamage and Wrinkles
|
Phase 2 | |
| Active, not recruiting |
NCT06170346 -
Effect of Topical Agents With Various Antioxidant Containts on Photodamage Skin Induced
|
Phase 2 | |
| Completed |
NCT02736760 -
Daylight-PDT With MAL for AK and Photodamaged Skin
|
Phase 4 | |
| Active, not recruiting |
NCT05456334 -
New Treatments for Actinic Keratoses of the Scalp
|
N/A | |
| Completed |
NCT05423873 -
A Multi-Center, Open-label Study Evaluate the Efficacy and Tolerability of a Dual Skincare Regimen Treatment for Facial Hyperpigmentation and Photodamaged Skin in Patients Exposed to Extrinsic Factors of Aging
|
N/A | |
| Not yet recruiting |
NCT05908825 -
Placebo-Controlled Study Assessing the Use of a Novel Exfoliative Serum With A Chemical Peel to Improve Photodamage in Adults
|
N/A | |
| Active, not recruiting |
NCT05963204 -
A Study to Evaluate the Effects for Midface Improvement When Pairing a Biostimulator With a Skincare Regimen
|
N/A | |
| Recruiting |
NCT04523961 -
Comparative Study of Two Topical Anesthetics Prior to Fractional Nonablative Laser Treatment of the Face
|
Phase 2/Phase 3 | |
| Completed |
NCT01787461 -
A Study to Assess the Effects of an Oral Dietary Supplement on Overall Facial Appearance Among Healthy Adult Women With Existing Skin Damage From Sun Exposure
|
Phase 4 | |
| Recruiting |
NCT06351358 -
Evaluation of the Effects of a Biostimulator and Dermal Fillers for Cheek Augmentation and Contour Deficiencies
|
N/A | |
| Completed |
NCT04065035 -
A Clinical Study to Evaluate Efficacy and Tolerability of a Cosmetic Product for Arm Firming
|
N/A | |
| Active, not recruiting |
NCT04096742 -
Altreno for Chest Rejuvenation
|
Phase 4 | |
| Completed |
NCT02693054 -
Safety and Efficacy Study for Various Skin Conditions
|
N/A | |
| Terminated |
NCT00375141 -
Long-Pulsed Dye Laser and Intense Pulsed Light for Skin Rejuvenation.
|
N/A |