Reliability of Serum Calcium to Phosphorus (Ca/P) Ratio as an Accurate and Inexpensive Tool to Define Disorders of Ca-P Metabolism

Phosphorus and Calcium Disorders Clinical Trial

Official title: Serum Calcium to Phosphorus (Ca/P) Ratio to Define Disorders of Ca-P Metabolism

Status Completed

Clinical Trial Summary

BACKGROUND: Primary hyperparathyroidism (PHPT) is the third most common endocrine disorder. The Ca/P ratio is an accurate tool to differentiate patients with PHPT (>3.5 if Ca and P are expressed in mg/dl) from healthy subjects. The reliability of this index is based on the fact that serum Ca and P are inversely related together. However, other disorders of the Ca-P metabolism, such as hypophosphoremia (HypoP) not related to PHPT, might also impair the Ca/P ratio.

OBJECTIVE: To validate the accuracy of Ca/P ratio in the diagnosis of Ca-P metabolism disorders, including also patients with documented HypoP not related to PHPT.

METHODS: A single-center, retrospective, case-control study will be carried out.

Biochemical measurements will include parathormone (PTH), vitamin D, serum Ca and P, serum albumin and creatinine.

Clinical Trial Description

n/a

Related Conditions & MeSH terms

• Disease
• Phosphorus and Calcium Disorders

• NCT number: NCT03603444
• Study type: Observational
• Source: Azienda Ospedaliero-Universitaria di Modena
• Status: Completed
• Start date: January 1, 2011
• Completion date: January 1, 2018