Renal Cell Carcinoma Clinical Trial
Official title:
Visualizing VEGF Producing Lesions in Von Hippel-Lindau Disease
Von Hippel Lindau disease (VHLD) is an inherited syndrome characterized by vascular
malformations, kidney cancer, adrenal gland and pancreas tumors. The VHL protein is not
functional in the different disease associated lesions which results in production of high
amounts of vascular endothelial growth factor (VEGF). Currently there are no clinical,
radiographic or molecular markers that can predict the natural history of a given lesion.
With 89Zr-bevacizumab positron emission tomography (PET) scanning, VEGF can be visualized
and quantified.
The investigators hypothesize that 89Zr-bevacizumab PET imaging is a useful tool to predict
the behaviour of disease associated lesions in patients with VHLD.
Adult patients with VHLD who have had routine magnetic resonance imaging (MRI) scans of
central nervous system (CNS) and abdomen will undergo a 89Zr-bevacizumab PET scan. MRI will
be repeated within 12 months.
n/a
Observational Model: Cohort, Time Perspective: Prospective
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