Pharmacology, Clinical Clinical Trial
Official title:
Relative Bioavailability and Food Effect Study of Two Oral Liquid Formulations in Comparison to a 1 mg Tablet of Riociguat to Characterize Its Pharmacokinetic Properties in Healthy Male and Female Adult Subjects in a Randomized, Open Label, 5-fold Crossover Design
Primary objective: To determine oral bioavailability of the liquid formulation intended for
pediatric use and potential food effects in healthy adults.
Secondary objective: To evaluate safety and tolerability measured by physical examination
findings, vital signs, electrocardiogram (ECG), laboratory parameters, and adverse events
(AEs).
Clinical pharmacology ;
Allocation: Randomized, Endpoint Classification: Bio-availability Study, Intervention Model: Crossover Assignment, Masking: Open Label
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