Pharmacokinetics Clinical Trial
Official title:
Pharmacogenetics of Bupropion Metabolism
The aim of the investigators research is to see if variants in a particular gene (named CYP2B6) affect how the body metabolizes (breaks down) certain medications, including the drug bupropion. Bupropion is widely used in the treatment of depression and for helping people quit smoking. Genes are portions of DNA that code for particular proteins in the body. The investigators are studying the gene that codes for a protein called CYP2B6. Differences in the structure of the gene are called variants and may mean that a person metabolizes a drug faster or slower than a person with a different variant.
Bupropion is widely used in the treatment of depression and for smoking cessation. It's most
abundant metabolite, hydroxybupropion, may be responsible for most of the therapeutic effect
of bupropion under conditions of long term dosing. Because the primary enzyme involved in
metabolism of bupropion to hydroxybupropion is the liver enzyme CYP2B6, we propose to study
the effect of different CYP2B6 genotypes on the metabolism of bupropion. These data will
guide the use of genotypes as a surrogate for measuring drug blood levels in studying
genetic determinants of outcomes for bupropion treatment.
A minimum of Forty-four subjects with 4 different CYP2B6 genotypes will participate in a
7-day study in which they take bupropion as outpatients for 6 days (to achieve steady state
drug levels) and then come to the San Francisco General Hospital (SFGH) Clinical Research
Center for a 1-day admission during which multiple blood and urine samples will be collected
for pharmacokinetic analysis.
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Observational Model: Case-Only, Time Perspective: Cross-Sectional
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