Pharmacokinetics Clinical Trial
Official title:
Pharmacokinetics of 11-Nor-9-carboxy-D9-tetrahydrocannabinol (THCCOOH) and Its Acyl-glucuronide (THCCOOH-GLu) After Intravenous Administration of THCCOOH in Healthy Human Subjects
A study on the fate and elimination of 11-Nor-Delta9-carboxy-9-tetrahydrocannabinol was up
to now not conducted, except of one single experiment in which (lacking)
psychopharmacological activity was tested after intravenous infusion of 20 mg in a human
individual. In this study, however, the authors did not trace the above questions due to
analytical and methodological deficits.
Aim of the study is to determine the pharmacokinetics of THCCOOH and THCCOOH-Glu after
intravenous ad-ministration of 5 mg THCCOOH in healthy individuals
Status | Completed |
Enrollment | 10 |
Est. completion date | March 2005 |
Est. primary completion date | |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Male |
Age group | 18 Years to 50 Years |
Eligibility |
Inclusion Criteria: - Good state of health (physically and mentally) Exclusion Criteria: - Any regular drug treatment within the last two months - Any intake of a substance known to induce or inhibit drug metabolising enzymes or transport systems within a period of less than 10 times the respective elimination half-life - Any acute or chronic illness or clinically relevant findings in the pre-study examination - Allergies (except for mild forms of hay fever) or history of hypersensitivity reactions - Smoking (regular or irregular) - Excessive alcohol drinking (more than approximately 30 g alcohol per day) - Positive drug screening especially THC or known or admitted drug abuse |
Time Perspective: Prospective
Country | Name | City | State |
---|---|---|---|
Germany | Clinical Research Center, Department of Internal Medicine VI | Heidelberg |
Lead Sponsor | Collaborator |
---|---|
Heidelberg University |
Germany,
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