Pharmacokinetic Clinical Trial
Official title:
Investigation of the Pharmacokinetic Properties of CG5503 After 2 Minutes Intravenous Infusion With and Without Oral Coadministration of Charcoal in a Randomised, Open, Single Dose, 2-way Crossover, Phase I Study in 12 Healthy Male Volunteers
This was a Phase I study in 12 healthy male participants to compare the pharmacokinetic
properties of CG5503 (how it is taken up and excreted from the body) after 2 minutes
intravenous (i.v.) infusion with and without oral co-administration of charcoal to
investigate a potential gastrointestinal secretion of CG5503.
During the course of the study each participant received two infusions of 40 mg CG5503
without (treatment A) and with (treatment B) oral co-administration of charcoal. In treatment
B, eight doses of 5 grams charcoal powder were co-administered orally at defined time points.
The wash out phases were to be at least 4 to 14 days between the treatment periods.
n/a
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