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Clinical Trial Summary

It is general that there are many factors for individual differences of drugs in clinical application, of which genetic factors accounted for more than 20%. Ticagrelor is a new-type receptor antagonist of P2Y12 and it is not affected by the influence of CYP2C19 polymorphism. With lack of predicted biomarkers, especially the research data of Chinese, it has the important significance in studying individual differences of ticagrelor in the antiplatelet efficacy and safety, through the pharmacogenomics research. The aim of this study is to determine the polymorphism of drug metabolizing enzymes, drug transporters and drug target genes in Chinese population. By detecting the gene polymorphism, we intend to study the pharmacokinetic/ pharmacodynamics/ pharmacogenomics (PK-PD-PG) correlation of ticagrelor and provide scientific basis for accurate medication guide for people to use ticagrelor.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT03161002
Study type Observational
Source Peking University First Hospital
Contact Qian Xiang, Ph.D
Phone +86 010 66110802
Email xiangqz@126.com
Status Recruiting
Phase
Start date May 31, 2017
Completion date December 2021

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