Clopidogrel And Ticagrelor in Healthy Subjects

Status Completed

Clinical Trial Summary

To evaluate the pharmacodynamics of a lower Ticagrelor dose in healthy Korean volunteers compared with standard Clopidogrel agent.

Clinical Trial Description

Consist with previous study Ticagrelor had greater, faster and more the platelet inhibition effect than Clopidogrel in both healthy subjects and stable coronary artery disease patients. Moreover, Asian subjects exposed higher active metabolite and stronger pharmacodynamics response than European subjects with same oral dose of antiplatelet agent. However, previous report comparing the efficacy and safety of Ticagrelor and Clopidogrel in healthy Asian ethnicity is lacking. Therefore, the aim of this study is to evaluate the pharmacodynamic responses of a lower Ticagrelor dose using laboratory platelet function tests in healthy Korean volunteers. ;

Study Design

Related Conditions & MeSH terms

Pharmacodynamics

Clinical Trial Details

NCT number	NCT02086903
Study type	Interventional
Source	Dong-A University
Contact
Status	Completed
Phase	Phase 3
Start date	February 2014
Completion date	May 2014

View Details

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