Pesticide Poisoning Clinical Trial
Official title:
Evaluation of Pesticide Exposure in the General Population: Use of Spatial, Environmental, Toxicological and Biological Approaches
An association has been suggested with several diseases including cancer and IARC has
classified several pesticides as carcinogenic, probably carcinogenic. There is a need for a
better characterisation of environmental pesticides exposures and identification of suitable
biomarkers of exposure and effect. A better understanding of the impact of pesticide exposure
on metabolomic, transcriptomic and epigenetic changes, is essential to strengthen
epidemiological hypotheses on the association with several cancer types.
The main objective of the project is to validate a GIS (geographic information system) based
method to assess environmental pesticide exposures, using environmental (contamination of
housedust) and biological (blood and urine samples) measures. The project aims further to
investigate a potential link between housedust contamination and biological measures in
healthy non-smoking male residents and explore the impact of environmental pesticide exposure
on metabolomics, transcriptomic and epigenetic parameters.
The project involves a pilot phase involving repeated (twice) sampling in 20 male non-smoking volunteers living in the Beaujolais region (France) to perform appropriate calibrations for metabolomic, transcriptomic and epigenetic analyses. The main study will be conducted in a sample of 150 male non-smoking volunteers and 50 professional pesticides applicators from the same region (3 sampling periods). ;
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