Autism Spectrum Disorder Clinical Trial
Official title:
Cognitive Enhancement Therapy for Adult Autism Spectrum Disorder
This study will investigate and contrast the effects of two psychological treatments for adults with autism spectrum disorder. Cognitive Enhancement Therapy (CET) is a cognitive remediation intervention that aims to help adults with problems in thinking, planning, and socialization. Enriched Supportive Therapy (EST) is an individual supportive therapy that aims to help adults learn about their condition, manage their emotions and stress, improve their social skills, and cope with everyday problems.
Autism spectrum disorder (ASD) is characterized by marked impairments in social and
non-social cognitive ability that persist well into adulthood and contribute to significant
functional disability. The treatment of ASD has focused almost exclusively on children, and
few empirically supported interventions are available to address the core cognitive and
functional challenges individuals with ASD face as they transition to adulthood. This study
will investigate and contrast the effects of two psychological treatments for adults with
autism spectrum disorder. Cognitive Enhancement Therapy (CET) is a cognitive remediation
intervention that aims to help adults with problems in thinking, planning, and socialization.
Enriched Supportive Therapy (EST) is an individual supportive therapy that aims to help
adults learn about their condition, manage their emotions and stress, improve their social
skills, and cope with everyday problems.
Participation in this study will last 30 months. Potential participants must be able to
attend weekly treatment sessions in Pittsburgh, PA.
The study design is a 30-month (2.5 years) randomized-controlled trial, where eligible
participants will be randomized to the CET or EST study treatments. Participants will be
treated with the study interventions for 18 months, and then followed for 12 additional
months to assess the lasting impact of the study interventions. All participants will
complete cognitive, clinical, and neuroimaging (magnetic resonance imaging) assessments prior
to starting the study treatments and then at specified intervals thereafter to evaluate the
impact of the study treatments on cognition, adaptive function, and the brain.
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