Pertussis Clinical Trial
Official title:
Vaccine Responses in Infants After Acellular Pertussis Vaccination During Pregnancy in Thailand
Young infants are most vulnerable to severe disease and even death when infected with
Bordetella pertussis. The current vaccines and vaccination programs do not guarantee
protection of neonates from this disease. Maternal acquired pertussis-specific antibodies
show low concentrations with short persistence in newborns creating a susceptibility gap for
infection between birth and the first vaccinations. A possible strategy to protect infants
from birth is pertussis vaccination during pregnancy, which will increase the amount of
passively transferred maternal antibodies.
However, little is known regarding the effect of high titers of maternal antibodies on the
infants immune responses to different pertussis vaccines (whole cell versus acellular).
Humoral immune responses will be assessed in infants receiving whole cell versus infants
receiving acellular pertussis vaccines. Functionality of the antibodies will also be
analyzed.
n/a
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