Peritonsillar Abscess Clinical Trial
Official title:
Penicillin and Metronidazole in Treatment of Peritonsillar Abscess - Prospective, Double-blind, Randomized, Placebo-controlled Study
Verified date | April 2021 |
Source | Helsinki University Central Hospital |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Treatment of peritonsillar abscess varies. To study whether broad spectrum antibiotics are required in addition to abscess drainage, a prospective, double blind, placebo-controlled, randomized study on 200 adult patients with peritonsillar abscess is performed. 100 patients are given penicillin and metronidazole and 100 patients get penicillin and placebo. Recovery and recurrence are analyzed.
Status | Completed |
Enrollment | 200 |
Est. completion date | April 2011 |
Est. primary completion date | April 2011 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: - referring doctor suspects peritonsillar abscess - patient is voluntary - patient has daily access to his/her e-mail - patient speaks and understands Finnish of Swedish - female patients have adequate birth-control method - patient has peritonsillar abscess Exclusion Criteria: - allergy to penicillin - allergy to metronidazole - use of metronidazole in preceding one month - pregnancy - breast-feeding - renal insufficiency - liver insufficiency - alcoholism (drunk at least once a week) - participant in another clinical trial at the moment - treatment of peritonsillar abscess requires in-patient care - tonsillectomy during the next 30 days - army recruit |
Country | Name | City | State |
---|---|---|---|
Finland | Helsinki University Central Hospital | Helsinki |
Lead Sponsor | Collaborator |
---|---|
Helsinki University Central Hospital |
Finland,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Number of Participants With Recurrence of Peritonsillar Abscess | Number of participants with recurrence of peritonsillar abscess having metronidazole in addition to penicillin or penicillin and placebo. | 56 days | |
Secondary | Number of Participants Recovering From Peritonsillar Abscess | Number of participants recovering from peritonsillar abscess having metronidazole in addition to penicillin or penicillin and placebo. | 28 days |
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