Clinical Trials Logo
  1. Home
  2. Peritoneal Dialysis
  3. NCT06096558

The Effects of Melatonin on Cardiovascular and Bone Metabolism Markers in Peritoneal Dialysis Patients

Peritoneal Dialysis Clinical Trial

Official title:
Effects of Melatonin, as a Dietary Supplement, on Glycemic Parameters, Cardiovascular Disease Risk Factors, Bone Metabolism Markers and Quality of Life in Peritoneal Dialysis Patients

Clinical Trial Summary

The aim of this double-blind randomized clinical trial is to determine the effects of Melatonin on cardiovascular disease risk factors, bone metabolism markers, serum concentrations of advanced glycated end products and quality of life in peritoneal dialysis patients. Forty patients from peritoneal dialysis centers will randomly assign to either Melatonin or placebo group. The patients in Melatonin group will receive 5 mg Melatonin (as 1 tablet) daily for 10 weeks, while the placebo group will receive identical placebo. At the baseline and the end of the study,7 ml blood will be collected from each patient after a 12-14-hours fasting and Serum concentrations of malondialdehyde; high sensitivity c-reactive protein; Soluble intercellular adhesion molecule-1; glucose; pentosidine; carboxy-methyl lysine; Procollagen 1 Intact N-Terminal Propeptide; Tartrate-resistant acid phosphatase 5b; osteoprotegerin; Receptor activator of nuclear factor kappa-Β ligand; Intact parathyroid hormone; triglyceride; total cholesterol; High-density lipoprotein cholesterol; low-density lipoprotein cholesterol; lipoprotein-a; albumin; calcium; phosphorous; and also systolic blood pressure; diastolic blood pressure and questionnaires including quality of life; quality of sleep and depression will be assessed.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06096558
Study type Interventional
Source National Nutrition and Food Technology Institute
Contact zahra yari
Phone +982122357484
Email zahrayari_nut@yahoo.com
Status Not yet recruiting
Phase N/A
Start date October 20, 2023
Completion date May 1, 2024
View Details
See also
  Status Clinical Trial Phase
Not yet recruiting NCT04925674 - Study of HEC53856 in Patients With Subjects With End-Stage Renal Disease Receiving Dialysis. Phase 1
Terminated NCT03438877 - Intensive Versus Regular Dosage For PD In AKI. N/A
Completed NCT05149508 - Intraperitoneal Pressure Measurements in Children
Not yet recruiting NCT04900610 - The Effect of Vitamin K2 Supplementation on Arterial Stifness and Cardiovascular Events in PEritonial DIAlysis N/A
Withdrawn NCT03019159 - Assessment of a Follow-up With Tele-consulting for Patients With Renal Failure Under Peritoneal Dialysis N/A
Recruiting NCT01195519 - The Assessment of Quality of Life in Patients With Peritoneal Dialysis and Hemodialysis N/A
Recruiting NCT06351007 - Educational Program on Dietary Adherence and Nutritional Knowledge in Chronic Kidney Disease Patients (EPAK) N/A
Not yet recruiting NCT04628117 - Effect of Oral Nutritional Supplementation on Oxidative Stress in Protein-energy Wasting Patients With Peritoneal Dialysis N/A
Recruiting NCT05449067 - CAPD Versus APD in Nondiabetic Peritoneal Dialysis Patients N/A
Not yet recruiting NCT03953950 - Effect of Add-on Spironolactone to Losartan Versus Losartan Alone on Peritoneal Membrane Among Peritoneal Dialysis Patients Phase 4
Completed NCT02128347 - Effectiveness of an Online Portal for Delivery of Care to Home Dialysis Patients N/A
Completed NCT01209273 - Comparison of Quality of Life on Automated Peritoneal Dialysis and Continuous Ambulatory Peritoneal Dialysis N/A
Completed NCT00734552 - Study to Evaluate the Protective Effect of α-Keto Acid With Low-protein Diet on Renal Function in PD Patients N/A
Completed NCT04413266 - Effects of Curcumin Supplementation in Patients With Chronic Kidney Disease on Peritoneal Dialysis N/A
Not yet recruiting NCT06060951 - Relating Abdominal Complications With Peritoneal Pressure Estimation and Reporting
Completed NCT03980795 - Exercise in Peritoneal Dialysis Patients (PDEX) N/A
Not yet recruiting NCT02270229 - Evaluation of the Peritoneal Dialysis Program in a Hospital in Chinandega, Nicaragua. N/A
Completed NCT02347592 - Peritoneal Dialysis Catheter Function N/A
Withdrawn NCT00397358 - Effect of Extraneal (Icodextrin)on Triglyceride Levels in PD Patients Phase 4
Completed NCT04666844 - Predicting Transfers to Hemodialysis in Peritoneal Dialysis Patients Using the Surprise Question