Faster Peritoneal Solute Transfer Rate and Survival in a Pre-APD and Icodextrin Peritoneal Dialysis Cohort

Peritoneal Dialysis Clinical Trial

Official title:

Faster Peritoneal Solute Transfer Rate and Survival in a Pre-APD and Icodextrin Peritoneal Dialysis Cohort

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05381051
• Other study ID #: 2016[099]K
• Status: Completed
• Start date: January 1, 2015
• Est. completion date: December 31, 2020

Study information

• Verified date: May 2022
• Source: RenJi Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

A fast peritoneal solute transfer rate (PSTR) has been linked to worse survival especially in continuous ambulatory peritoneal dialysis (PD) cohort. In more recent cohorts, where automated PD and icodextrin were more widely used, this association disappears. The current study intended to clarify whether fast PSTR is related to worse outcome in this single center cohort with minimal use of APD and no icodextrin and otherwise modern management practice. Our study found that baseline PSTR predicted patient outcome in univariate survival analysis but not in multivariate analysis. The relationship between comorbidity and faster baseline PSTR may partly explain it.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 430
• Est. completion date: December 31, 2020
• Est. primary completion date: December 31, 2018
• Accepts healthy volunteers: No
• Gender: All
• Age group: N/A and older

Eligibility

Inclusion Criteria:

1. Patients are Han Chinese;

2. Patients prepare for dialysis in our center, and start PD within 3 months after abdominal catheterization;

3. Patients successfully complete the first peritoneal equilibration test(PET);

4. Follow up regularly in our PD center.

Exclusion Criteria:

1. Patients from hemodialysis to peritoneal dialysis;

2. Patients who need peritoneal dialysis due to transplant-renal loss;

Related Conditions & MeSH terms

• Peritoneal Dialysis

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
RenJi Hospital

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	The relationship between fast PSTR and worse outcome in PD.	Baseline PSTR predicted patient outcome in univariate survival analysis but not in multivariate analysis. The relationship between comorbidity and faster baseline PSTR may partly explain it.	The data collection time period of the study is over 10 years.