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Clinical Trial Details — Status: Recruiting

Administrative data

NCT number NCT00990171
Other study ID # 200906084R
Secondary ID
Status Recruiting
Phase N/A
First received October 5, 2009
Last updated April 11, 2014
Start date December 2011

Study information

Verified date April 2014
Source National Taiwan University Hospital
Contact Jenq-Wen Huang, MD
Phone +886-2-23123456
Email 007378@ntuh.gov.tw
Is FDA regulated No
Health authority Taiwan: Department of Health
Study type Observational

Clinical Trial Summary

A prospective long-term follow up of peritoneal dialysis patients' outcome correlates with nutritional status and body composition.


Description:

Wasting and malnutrition are common and serious complications in patients on peritoneal dialysis and are strongly associated with adverse outcomes. Techniques for assessing nutrition have limitations and, due to metabolic effects and confounding effects of altered hydration and other body composition abnormalities, these limitations are greater in the context of renal failure. Bioelectrical impedance analysis is a promising method for the objective assessment and monitoring of body composition. Body composition techniques subdivide the body into compartments on the basis of differing physical properties. The different compartments reflect hydration, nutrition/wasting, body fat, and bone mineral content, which are all of great importance in patients on peritoneal dialysis. We will conduct a prospective long-term follow up of PD patients' outcome correlates with nutritional status and body compositions. The patients will receive BIA every three months, and other routine clinical data such as dialysis adequacy, peritoneal equilibration test and monthly biochemical data are collected to analyze. An additional blood sample 8 ml and 5 ml dialysate of overnight, 0 hour, 2 hour and 4 hour will be collected during annual PET for other inflammatory cytokines and nutritional markers such as adiponectin, leptin, ghrelin, prealbumin and transferrin. The follow up period will be as long as possible and the last recruited into this study is in the Aug 2014. These data will be used for the morbidity and mortality analysis to see if body compositions will be more useful and timely than the other nutritional parameters.


Recruitment information / eligibility

Status Recruiting
Enrollment 300
Est. completion date
Est. primary completion date December 2016
Accepts healthy volunteers No
Gender Both
Age group 20 Years to 90 Years
Eligibility Inclusion Criteria:

1. Patients at National Taiwan University Hospital

2. Patients who have received PD more than 3 months

3. Patients who sign the informed consents

Exclusion Criteria:

1. Patients who have received PD less than 3 months

2. Patients who refuse to sign informed consents

3. Patients who refuse to draw additional blood for research

Study Design

Observational Model: Cohort, Time Perspective: Prospective


Locations

Country Name City State
Taiwan National Taiwan University Hospital Taipei

Sponsors (1)

Lead Sponsor Collaborator
National Taiwan University Hospital

Country where clinical trial is conducted

Taiwan, 

Outcome

Type Measure Description Time frame Safety issue
Primary Measure BCM could be a nutrition status marker 5 yrs Yes
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