Clinical Trials Logo

Clinical Trial Summary

Cytoreductive surgery (CRS) with the addition of hyperthermic intraperitoneal chemotherapy (HIPEC) is used in current clinical practice in selected patients with advanced ovarian cancer. Clinical evidence for the benefit of HIPEC in ovarian cancer comes from the pivotal phase 3 OVHIPEC trial. Worldwide, two established strategies exist for dosing of HIPEC protocols, which follow either a body surface area (BSA)-based or a concentration-based approach. Since both strategies result in different exposure to intra-peritoneal chemotherapy, we aim to compare the pharmacokinetics and safety of both strategies.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT05406674
Study type Interventional
Source The Netherlands Cancer Institute
Contact W. van Driel, MD PhD
Phone +31 20 512 9111
Email w.v.driel@nki.nl
Status Recruiting
Phase Phase 2
Start date June 15, 2022
Completion date December 2024

See also
  Status Clinical Trial Phase
Not yet recruiting NCT04983550 - Efficacy and Safety of SG001 Combined With PLD in Patients With Platinum-resistant Relapsed EOC Phase 2
Completed NCT01610206 - A Randomized Study of Safety and Efficacy of Pazopanib and Gemcitabine in Persistent or Relapsed Ovarian Cancer Phase 2
Completed NCT00768144 - Sunitinib in Recurrent and Refractory Ovarian, Fallopian Tube and Peritoneal Carcinoma Phase 2
Suspended NCT00753480 - A Study of D4064A Administered to Patients With Recurrent or Persistent Epithelial Ovarian, Primary Peritoneal, or Fallopian Tube Cancer Phase 1
Completed NCT00801320 - Primary Tumor Harvest for the Purpose of Possible Use in a Future Clinical Trial in Patients With Ovarian, Fallopian Tube or Primary Peritoneal Cancer N/A
Recruiting NCT02349958 - Clinical Trial of Intraperitoneal Hyperthermic Chemotherapy Phase 2
Completed NCT00268918 - Docetaxel and PTK787 in Metastatic Breast Cancer Patients and Gynecological Cancer Patients Phase 1
Completed NCT00230542 - Carboplatin and Pemetrexed in Recurrent Platinum Sensitive Ovarian Cancer Phase 2
Completed NCT00461786 - A Study of Single Agent Pemetrexed Disodium in Treating Patients With Recurrent or Persistent Ovarian or Primary Peritoneal Cancer Phase 2
Terminated NCT00505661 - Letrozole in Patients With Ovarian Tumors Phase 2
Completed NCT02865811 - Pembrolizumab Combined With PLD For Recurrent Platinum Resistant Ovarian, Fallopian Tube Or Peritoneal Cancer Phase 2
Recruiting NCT05009082 - Niraparib vs Niraparib Plus Bevacizumab in Patients With Platinum/Taxane-based Chemotherapy in Advanced Ovarian Cancer Phase 3
Recruiting NCT05001282 - A Study to Evaluate ELU001 in Patients With Solid Tumors That Overexpress Folate Receptor Alpha (FRĪ±) Phase 1/Phase 2
Recruiting NCT04907643 - Virtual Reality for GI Cancer Pain to Improve Patient Reported Outcomes N/A
Completed NCT01891344 - A Study of Rucaparib in Patients With Platinum-Sensitive, Relapsed, High-Grade Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer (ARIEL2) Phase 2
Recruiting NCT05887609 - An Evaluation of Maintenance Therapy Combination Mirvetuximab Soravtansine and Olaparib Phase 2
Active, not recruiting NCT02470299 - Evaluation of GTPase Inhibition by Post-operative Intravenous Ketorolac in Ovarian Cancer Patients N/A
Recruiting NCT06184867 - Choices About Genetic Testing And Learning Your Risk With Smart Technology Early Phase 1
Recruiting NCT04516447 - A Study of ZN-c3 in Patients With Platinum-Resistant Ovarian Cancer Phase 1
Completed NCT04088786 - Phase I Trial HIPEC With Nal-irinotecan Phase 1