Ovarian Cancer Clinical Trial
Official title:
Phase II Study of Carboplatin and Pemetrexed in Patients With Recurrent Platinum Sensitive Ovarian, Fallopian Tube or Primary Peritoneal Cancer
The purpose of this study is to determine the effects (good and bad) the combination of carboplatin and pemetrexed have on patients with recurrent ovarian, peritoneal, or fallopian tube cancer.
- Before patients receive any chemotherapy treatments they will be given three medications
to prevent side effects from the chemotherapy drugs. These medications are vitamin B12,
folic acid and dexamethasone.
- Chemotherapy treatments will be given intravenously in the outpatient clinic. Pemetrexed
will be given first and will take 10 minutes to infuse followed by carboplatin which
will take 30-45 minutes to infuse. These treatments will be repeated once every three
weeks for 6 cycles of chemotherapy (18 weeks).
- Before each chemotherapy treatment the following tests and procedures will be performed:
physical exam and medical history; evaluation of ability to undertake daily activities;
and blood tests.
- After every 2 cycles of chemotherapy (every 6 weeks) patients will have a CT or MRI scan
to measure how well their cancer is responding to treatment.
- The study treatment will last for 6 cycles of chemotherapy as long as the tumor does not
grow and the patient isn't experiencing any severe side effects.
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