Clinical Trials Logo
  1. Home
  2. Periprosthetic Joint Infection
  3. NCT05495815

Proper Duration of Suppressive Antibiotic Therapy After Debridement, Antibiotics, and Implant Retention — ProperSAT  

Periprosthetic Joint Infection Clinical Trial

Official title:
Randomized Clinical Trial Determining Proper Duration of Suppressive Antibiotic Therapy After Total Joint Arthroplasty Debridement, Antibiotics, and Implant Retention

Clinical Trial Summary

Multiple studies have demonstrated oral suppressive antibiotic therapy (SAT), after intravenous antibiotics, maximizes reoperation-free survival of total joint arthroplasty (TJA) debridement, antibiotics, and implant retention (DAIR) for acute periprosthetic joint infection (PJI). However, little is known regarding sequelae of SAT after DAIR for PJI. Prior studies have small or heterogeneous patient cohorts, variable antibiotic regimens, arrive at disparate conclusions, and do not establish antibiotic resistance risk. The investigators propose a prospective randomized controlled multicenter study to expand on findings in a retrospective, multi-center pilot study. Study aims are to evaluate SAT after DAIR of acutely infected primary TJA regarding: 1) adverse drug reactions/intolerance; 2) reoperation for infection; and 3) antibiotic resistance.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05495815
Study type Interventional
Source University of Maryland, Baltimore
Contact
Status Recruiting
Phase N/A
Start date April 2024
Completion date June 2026
View Details
See also
  Status Clinical Trial Phase
Recruiting NCT02530229 - Arthrocentesis Study N/A
Recruiting NCT06126614 - Infection Prophylaxis in Total Joint Replacement Phase 3
Enrolling by invitation NCT05640336 - Treatment of Acute Periprosthetic Joint Infection Comparing Single and Planned Double-Debridement Antibiotics and Implant Retention Followed by Chronic Antibiotic Suppression N/A
Completed NCT03139539 - Intraoperative Microbial Contamination N/A
Recruiting NCT06268795 - A Diagnostic Test Accuracy Study Comparing Biopsy to Aspiration in Shoulder and Elbow Arthroplasty Revision Surgery (BASE Study)
Recruiting NCT05357287 - Closed Incisional Negative Pressure Wound Therapy in Post-surgical Wound Care of Patients With Periprosthetic Joint Infection N/A
Active, not recruiting NCT05084378 - Evaluation of Emerging New Treatments for Infection Prevention in Total Joint Replacement Phase 3
Recruiting NCT02868736 - Clinical Validation of CD Diagnostics Synovasure PJI ELISA Test and Synovasure PJI Lateral Flow Test for Detection of Periprosthetic Joint Infection in Synovial Fluid N/A
Not yet recruiting NCT06464770 - Optimizing Infection Prophylaxis Prior to Shoulder Surgery N/A
Terminated NCT04274517 - Microbial Growth in Operative Splash Basins During Total Joint Arthroplasty N/A
Recruiting NCT05284318 - Prospective Cohort Study on Antibiotic Course and Efficacy After Two-stage Revision in PJI.
Not yet recruiting NCT06428448 - Study to Evaluate the REMEDY SPECTRUM IM Spacer Nail in the Treatment of Ankle-Related Infections Phase 2
Not yet recruiting NCT06189885 - Preoperative Daptomycin Prophylaxis in Two-Stage Exchange Arthroplasty: A Prospective, Randomized, Double-Blinded Trial N/A
Enrolling by invitation NCT05320354 - Diagnosis and Bacterial Identification of Periprosthetic Joint Infection With Microbial-ID