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Peripheral Vascular Disease clinical trials

View clinical trials related to Peripheral Vascular Disease.

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NCT ID: NCT03238222 Recruiting - Clinical trials for Peripheral Arterial Disease

Motivating Structured Walking Activity in Intermittent Claudication

MOSAIC
Start date: November 10, 2017
Phase: N/A
Study type: Interventional

Peripheral arterial disease can cause leg pain or discomfort (called intermittent claudication (IC)), which limits the ability to walk and carry out everyday activities. Lifestyle changes, like increasing walking, can lead to improvements, but can be a challenge to begin and then continue. The aim of this study is to investigate if a physiotherapist-led, behaviour change treatment effects walking in people with IC. The treatment is designed to build an understanding of IC and walking exercise and help individuals develop strategies to increase regular walking. The trial will recruit 192 adults (aged 50 years and over) with IC. All participants will visit King's College London or their local hospital to complete two short walking tests and answer questionnaires about their daily activities, beliefs about their symptoms and treatment, quality of life and the costs of having IC. Participants will then be randomly assigned to receive either the new treatment or continue with their usual NHS care. The new treatment involves two 60-minute face-to-face sessions (at the participant's home or local hospital) and two 20-minute telephone calls with a physiotherapist who will discuss participants' understanding and beliefs about IC, walking and help participants to set goals and plans to increase walking over 12 weeks. Participants will be provided with a step counter (pedometer) and walking record. After 12 weeks, all participants will attend a second appointment where they will repeat the walking tests and fill out another set of questionnaires. A final set of questionnaires will be completed by all participants after 6 months (by post or electronically). Some participants will be invited to provide feedback on their experience of the treatment and trial by telephone or a face-to-face interview with a researcher.

NCT ID: NCT03207451 Completed - Clinical trials for Coronary Artery Disease

Vorapaxar on Thrombin Generation and Coagulability

Start date: January 1, 2016
Phase: Phase 4
Study type: Interventional

This investigation will be conducted in patients 18-75 years of age with multiple coronary artery disease risk factors (antiplatelet naïve patients) and patients with prior MI or PVD on antiplatelet therapy. Pharmacodynamics will be assessed at multiple time points to assess onset-, maintenance-, and offset-effect of vorapaxar on thrombin generation, platelet reactivity, and plasma/platelet endothelial and inflammatory biomarkers. Safety assessment will be assessed throughout the study.

NCT ID: NCT03206762 Completed - Clinical trials for Peripheral Vascular Disease

JET-RANGER Trial - JETStream Atherectomy With Adjunctive Paclitaxel-Coated Balloon Angioplasty vs Plain Old Balloon Angioplasty Followed by Paclitaxel-Coated Balloon

Start date: March 28, 2018
Phase: N/A
Study type: Interventional

A prospective, multicenter, randomized study evaluating the use of Jetstream Atherectomy (JS) followed by DCB in comparison to the use of plain old balloon angioplasty (POBA) followed by DCB alone in the treatment of complex lesions in femoropopliteal arteries in subjects with claudication (Rutherford Clinical Category (RCC) of 2-4) (complex lesions are defined as long (≥ 10 cm) lesions, or moderately or highly calcified lesions, or chronic total occlusions irrespective of length).

NCT ID: NCT03037255 Completed - Diabetes Mellitus Clinical Trials

Association of Long-term Conditions With Survival Following Heart Attack in England and Wales

Start date: January 2003
Phase:
Study type: Observational [Patient Registry]

This study aims to determine the extent to which pre-existing long-term conditions are associated with survival following a heart attack (acute myocardial infarction) using observational data from the UK's national heart attack register.

NCT ID: NCT03028285 Completed - Clinical trials for Peripheral Vascular Disease

Study of Safety and Tolerability of UNIFUZOL (Solution for Infusions) in Healthy Volunteers

Start date: July 15, 2016
Phase: Phase 1
Study type: Interventional

Unifusol (R) is a solution of arginine sodium succinate for intravenous infusions. Its effects include vasodilation, protection of inner layer of blood vessels and improvement of blood viscosity. The present phase I study is aimed to evaluate the safety and tolerability of Unifusol infusions in healthy volunteers.

NCT ID: NCT02993809 Not yet recruiting - Diabetic Foot Clinical Trials

Autologous Transplantation of BM-ECs With Platelet-Rich Plasma Extract for the Treatment of Critical Limb Ischemia

Start date: March 2018
Phase: Phase 1
Study type: Interventional

The intent of this clinical study is to evaluate the safety of the injection composed of autologous bone marrow derived endothelial cells (BM-ECs) and platelet-rich plasma extract (PRPE) for the treatment of critical limb ischemia.

NCT ID: NCT02935127 Not yet recruiting - Clinical trials for Peripheral Vascular Disease

Absorbable Sutures in Vascular Surgery

ASPeVaS
Start date: November 2016
Phase: N/A
Study type: Interventional

Absorbable sutures are not generally accepted by the majority of vascular surgeons for the possible complications such as the breakage of the suture at the anastomoses level. Some experimental and clinical studies in the current literature demonstrated that the use of absorbable sutures may even reduce some important complications such as restenosis. The aim of this study is to compare absorbable and non-absorbable sutures in patients undergoing peripheral vascular surgery with vein bypass grafting.

NCT ID: NCT02869087 Completed - Clinical trials for Peripheral Vascular Disease

The DESappear Study: Drug Eluting Scaffold

DESappear
Start date: October 10, 2016
Phase: N/A
Study type: Interventional

The aim of this study is to prospectively collect information to evaluate the safety and performance of the Akesys Prava Sirolimus Eluting Bioresorbable Peripheral scaffold system for the treatment of symptomatic primary atherosclerotic stenoses and occlusions of the superficial femoral artery (SFA).

NCT ID: NCT02850107 Completed - Clinical trials for Peripheral Vascular Disease

DiRectional AthErectomy + Drug CoAted BaLloon to Treat Long, CalcifIed FemoropopliTeal ArterY Lesions

REALITY
Start date: June 1, 2016
Phase: N/A
Study type: Interventional

This study is designed to collect information during a procedure that is routine care for treating a blockage in a blood vessel in the upper part of the participant's leg. This study is for data collection reasons to help doctors gain better understanding of the treatment of disease in the blood vessels of the legs. You will be treated with two devices that are routine, or standard of care, for your doctor to treat blockages in the blood vessel of the leg. The treatment is for a blockage or narrowing caused by plaque build-up in the blood vessel. Data will be collected to assess what length of time the blood vessel will be prevented from re-narrowing through twenty-four (24) months after the procedure.

NCT ID: NCT02834858 Recruiting - Diabetic Foot Clinical Trials

Umbilical Cord Mesenchymal Stem Cells Infusion for Diabetes Related Vascular Complications

Start date: January 2016
Phase: Phase 1
Study type: Interventional

Stem cell therapy has been a new and effective therapy in recent years for diabetic foot.This study intends to establish an optimal clinical research program, and attempts to break the technical bottleneck in the stem cell therapy for treating diabetes related vascular complications.