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Estrogen Receptors and Peripheral Artery Disease — ESTROPAD  

Peripheral Artery Disease Clinical Trial

Official title:
Molecular Analysis of Estrogen Receptors in Patients With Peripheral Artery Disease

Clinical Trial Summary

It is estimated that >200 million people have Peripheral artery disease (PAD) worldwide. PAD is related to increased morbidity or mortality in affected patients. More severe forms of PAD are surgically managed. Estrogen receptors (ERs) are strictly linked with vascular disease, and may be involved also in PAD onset and progression. This study will explore the expression of ERs, (ER-alpha, ER-beta,and a G protein-coupled of estrogen receptor -GPER-) in vessel wall of arteries of operated PAD patients, through the entire clinical spectrum of PAD.

Clinical Trial Description

PAD is the atherosclerotic obstruction of the arteries of the lower extremities and it is widespread especially in highly developed countries. The most common complication of PAD is critical limb ischemia with rest pain and leg ulcers. To date the pathophysiology of PAD is linked to atherosclerosis but other pathways are also under evaluation. A recent study (Serra et al) investigated the presence of ER-alfa, ER-beta, and GPER in the wall of normal and varicose veins.

The aim of this observational study is to evaluate the expression and the role of estrogen receptors in patients with PAD, and undergoing surgical treatment with reconstructive arterial surgery. Therefore, we will collect tissue samples from diseased arteries that will be further analyzed for ER expression. We will then correlate the results with the clinical spectrum of the patients. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04419727
Study type Observational
Source University of Catanzaro
Contact Raffaele Serra, M.D., Ph.D.
Phone +3909613647380
Email rserra@unicz.it
Status Recruiting
Phase
Start date January 2, 2020
Completion date November 2, 2020
View Details
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