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The Impact of Factor Xa Inhibition on Thrombosis, Platelet Activation, and Endothelial Function in Peripheral Artery Disease

Peripheral Arterial Disease Clinical Trial

Official title:
The Impact of Factor Xa Inhibition on Thrombosis, Platelet Activation, and Endothelial Function in Peripheral Artery Disease

Clinical Trial Summary

The purpose of this study is to understand how the drug rivaroxaban improves symptoms associated with peripheral artery disease.

Clinical Trial Description

The Primary Investigator's central hypothesis is that activation of thrombotic pathways and downstream effectors of factor Xa signaling contribute to the development of PAD and its complications. Aim 1: To assess the impact of rivaroxaban on macrovascular endothelial function in a randomized, double-blind, placebo-controlled crossover intervention in humans with PAD. Aim 2: To assess the impact of rivaroxaban on PAR-1-mediated platelet activation in addition to its pleiotropic effects on thrombosis, thrombolysis, and inflammation in a randomized, double-blind, placebo-controlled crossover intervention in humans with PAD. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05009862
Study type Interventional
Source Vanderbilt University Medical Center
Contact Paige V Yates, BS
Phone (615) 322-0930
Email paige.v.yates@vumc.org
Status Recruiting
Phase Phase 4
Start date April 19, 2022
Completion date March 1, 2025
View Details
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