Perioperative Pain Clinical Trial
Official title:
A Phase 2, Randomized, Double-Blind, Placebo-Controlled, Escalating Dose-Response Trial of Intravenous Adenosine for Perioperative Analgesia in Females Undergoing Abdominal Hysterectomy or Myomectomy
Adenosine A1 and A2 receptors are widely distributed in the brain and spinal cord and represent a non-opiate target for pain management. Activated spinal A1 receptors inhibit sensory transmission by inhibiting the slow ventral root potential, which is the C-fiber-evoked excitatory response associated with nociception. Adenosine may inhibit intrinsic neurons through an increase in K+ conductance and presynaptic inhibition of sensory nerve terminals to inhibit the release of substance P and perhaps glutamate. Although adenosine A3 receptors are not found in the nervous system, adenosine is also known to have anti-inflammatory properties that may contribute to pain relief in the peripheral setting of inflammation.
n/a
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Double-Blind, Primary Purpose: Treatment
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT06034873 -
Ultrasound Guided Pericapsular Nerve Block Versus iv Sedation Analgesia in Reduction of Shoulder Dislocation
|
Phase 2 | |
Completed |
NCT05002361 -
Effect of Dexamethasone Shortly Before Surgery on the Intraoperative Dose of Remifentanil
|
Phase 4 | |
Completed |
NCT04609033 -
Implications of Different Analgesic Models on Inflammatory Markers After Laparoscopic Cholecystectomy
|
N/A | |
Withdrawn |
NCT04813991 -
Pain Control Without Opioids
|
Phase 3 | |
Completed |
NCT04172649 -
Acupuncture With Press Tack Needles for Perioperative Pain After Open Radical Prostatectomy
|
N/A | |
Recruiting |
NCT04879004 -
EFFECT - EFFectiveness of ESPB (Erector Spinae Plane Block) in Laparoscopic Cοlectomies Trial
|
N/A | |
Not yet recruiting |
NCT05393726 -
Suprainguinal Fascia Iliaca Block Versus Lumbar Erector Spinae Plane Block for Oncologic Thigh Surgery
|
N/A | |
Recruiting |
NCT03744845 -
The Use of Virtual Reality to Reduce Anxiety and Pain in Perioperative Settings
|
N/A | |
Completed |
NCT05788458 -
Effect of Bupivacaine Concentration on Ultrasound Guided Pericapsular Group Nerve Block Efficacy in Hip Surgery Patients
|
Phase 4 | |
Completed |
NCT04320212 -
Lumbar Epidural Analgesia With Bilateral Erector Spinae Block for Pain Management in Lumbar Spine Surgery
|
N/A |