Magnesium Sulphate and Extubation Quality

Perioperative Complication Clinical Trial

Official title:

The Effect of Magnesium Sulfate on Extubation Quality Score and Recovery in Larynx Laser Microsurgery, Prospective, Randomized, Controlled Study

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05858957
• Other study ID #: Extubation quality
• Status: Completed
• Phase: Phase 4
• Start date: April 20, 2023
• Est. completion date: July 30, 2023

Study information

• Verified date: April 2023
• Source: Cukurova University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The investigators aimed to search effect of magnesium Sulfate on extubation quality scores, recovery and pain in larynx micro surgery. The patients allocated to two groups to receive magnesium sulfate 30 mg/kg in 100 ml saline infusion (maximum 2g) (Group m) or saline 100 ml (Group S) before induction of anesthesia. Anesthesia induction performed with propofol 2 mg/kg, rocuronium 0.6 mg/kg, remifentanil 0.5 µg/kg and general anesthesia maintained with total intravenous anesthesia (propofol 3-7 mg/kg, remifentanil 0.05-0.1 µg/kg/min and O2/air 30/70 mixture) to the all patients. Extubation quality scores, Extubation time, NRS scores were assessed.

Description:

The investigators aimed to search effect of magnesium sulfate on extubation quality, recovery feature and complications.98 adult patients scheduled for larynx laser microsurgery were included and randomly allocated to two groups to receive magnesium sulfate 30 mg/kg in 100 ml saline infusion (maximum 2g) (Group m) or saline 100 ml (Group S) before induction of anesthesia. Anesthesia induction performed with propofol 2 mg/kg, rocuronium 0.6 mg/kg, remifentanil 0.5 µg/kg and general anesthesia maintained with total intravenous anesthesia (propofol 3-7 mg/kg, remifentanil 0.05-0.1 µg/kg/min and O2/air 30/70 mixture) to the all patients. Paracetamol 15 mg/kg applied to all patients.Extubation quality score, extubation time, stay in postanesthesia unit (PACU) time, numeric rating scale (NRS) and complications were recorded.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 98
• Est. completion date: July 30, 2023
• Est. primary completion date: July 15, 2023
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 90 Years

Eligibility

Inclusion Criteria:

• 18 age over
• American society of Anesthesiology (ASA) clinical status I-III
• the patients who experience larynx micro surgery

Exclusion Criteria:

• under 18 years old
• ASA IV and over
• severe airway obstruction
• neuromuscular disease
• presence of tracheostomy

Related Conditions & MeSH terms

• Perioperative Complication

Intervention

Drug:
• Magnesium sulfate
magnesium sulphate IV 30 mg/kg (10 min) infusion apply to the Group M
• Saline
100 ml saline infusion apply to the Group S

Locations

Country	Name	City	State
Turkey	Cukurova University	Adana

Sponsors (1)

Lead Sponsor	Collaborator
Cukurova University

Country where clinical trial is conducted

Turkey, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	extubation quality scores	Extubation quality will assess with quality scores such as no cough, Mild cough, moderate cough, severe cough.	at the time between stop the total intravenous anesthesia and extubation of patient (last 20 min of anesthesia).
Secondary	extubation time	The time need to adequate spontaneous ventilation at recovery period	time between stop the total intravenous anesthesia and extubation of patient (last 20 min of anesthesia).