Perioperative Care Clinical Trial
Official title:
Effects of Preanesthetic Dexmedetomidine on Hemodynamic Responses to Endotracheal Intubation in Elderly Patients Being Treated for Hypertension: A Randomized Trial
Background: Dexmedetomidine is an alpha 2 adrenergic agonist with sedative, anxiolytic, and
analgesic properties. This study was designed to evaluate the inhibitory effects of
preoperative 0.5 μg/kg dexmedetomidine on hemodynamic responses caused by endotracheal
intubation in elderly patients being treated for hypertension.
Methods: Forty elderly (≥ 65 years) treated-hypertensive patients of American Society of
Anesthesiologists physical status II undergoing elective noncardiac surgery were randomly
and assigned to two groups. Group C received normal saline and group D received 0.5 μg/kg
dexmedetomidine intravenously over 10 min just before endotracheal intubation. Systolic
blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP) and heart
rate (HR) were recorded preoperatively at ward, immediately after study drug administration,
and at 1, 3, and 5 minutes after endotracheal intubation.
n/a
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Prevention
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