Periodontal Pocket Clinical Trial
Official title:
Clinical and Biochemical Effects of the Adjunctive Use of a Polynucleotides and Hyaluronic Acid Based Gel in the Subgingival Re-instrumentation of Residual Periodontal Pockets: a Randomized, Split-mouth Clinical Trial.
The purpose of this randomized controlled clinical trial (RCT) was to investigate the clinical and biochemical efficacy of a gel containing PDRN and HA used in association with subgingival re-instrumentation in the treatment of residual periodontal pockets.
The aim of the present study was to investigate the clinical and biochemical efficacy of a gel containing polynucleotides (PDRN) and hyaluronic acid (HA) used in association with subgingival re-instrumentation in the treatment of residual periodontal pockets. 50 patients were enrolled in a randomized, split-mouth clinical trial. For each patient, two teeth with similar residual pockets with probing depth (PD) ≥ 5 mm were selected to receive re-instrumentation with (test) or without (control) the adjunctive use of a PDRN and HA based gel. Differences in changes of PD, gingival recession (REC), clinical attachment level (CAL), modified sulcular bleeding index (mSBI), plaque index (PLI) from baseline to 6, 8, 24, 36 and 48 weeks were analyzed and the frequencies of sites with PD <4 mm at 48 weeks were compared. Furthermore, changes in the dosage of alpha-2-macroglobulin (α2M) and of matrix metalloproteinase-9 (MMP-9) from baseline to 6 weeks were evaluated. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT04712630 -
Non-Incised Papillae Surgical Approach (NIPSA) With and Without Graft
|
N/A | |
| Recruiting |
NCT03997552 -
NIPSA Versus Marginal Approach by Palatal Incision and MIST in Periodontal Regeneration
|
N/A | |
| Not yet recruiting |
NCT03588507 -
Clinical and Radiographic Evaluation of PPF With or Without NCHA Bone in Treatment of Intrabony Defects
|
N/A | |
| Completed |
NCT03364751 -
Effect of Switching From Cigarette Smoking to the Use of IQOS on Periodontitis Treatment Outcome
|
N/A | |
| Terminated |
NCT04639661 -
Predictors of Periodontal Outcomes Post-sanative Therapy
|
||
| Enrolling by invitation |
NCT05125835 -
Periodontal Maintenance and the COVID-19 Pandemic
|
||
| Not yet recruiting |
NCT03909568 -
Bone Height and Extractions Study
|
N/A | |
| Recruiting |
NCT05162417 -
Photodynamic in Periodontal Treatment
|
N/A | |
| Completed |
NCT02630173 -
Evaluation of Endodontic Status on Periodontal Healing of Concomitant Endodontic Periodontal Lesions
|
N/A | |
| Completed |
NCT02627326 -
Chlorhexidine Intracanal Medicament in Periodontal Healing in Concomitant Endo Perio Lesion With Communication
|
Phase 2 | |
| Completed |
NCT04082949 -
Autologous Fibrin Glue Application as an Adjunct to Nonsurgical Periodontal Treatment of Chronic Periodontitis
|
Early Phase 1 | |
| Completed |
NCT03074565 -
Ultrasonic Versus Ultrasonic+ for Effective Sanative Therapy
|
N/A | |
| Completed |
NCT03374176 -
Efficacy of Amoxicillin-metronidazole Compared to Clindamycin in Patients With Periodontitis and Diabetes
|
Phase 3 | |
| Completed |
NCT01860495 -
Gingival Crevicular Fluid Bone Morphogenetic Protein - 2 Release Profile Following the Use of Perforated Membrane
|
Phase 2 | |
| Completed |
NCT03358251 -
Investigation of the Safety and Efficacy of Pocket-X Gel
|
N/A | |
| Recruiting |
NCT03102892 -
Antimicrobial Photodynamic Therapy on Periodontal Treatment and Salivary Status of Type 1 Diabetes Mellitus Patients
|
N/A | |
| Recruiting |
NCT05315804 -
Treatment of Intraosseous Periodontal Defects With Amelogenins
|
N/A | |
| Not yet recruiting |
NCT04670133 -
Inulin Supplementation During Sanative Therapy to Further Improve Periodontal Healing
|
N/A | |
| Recruiting |
NCT05088746 -
Comparing Different Timings for Periodontal Re-evaluation After Non-surgical Periodontal Therapy (NSPT)
|
||
| Completed |
NCT04542746 -
Treatment of Periodontal Intraosseous Defects
|
N/A |