Periodontal Disease Clinical Trial
Official title:
A Prospective Randomized Clinical Trial of Doxycycline 20mg Twice a Day Versus Placebo on the Bleeding and Spotting in Women After Insertion of a Levonorgestrel Implant (Norplant) Protocol #2002-1
Irregular or prolonged menstrual bleeding and/or spotting are common side effects in patients using progestin-only hormonal contraception such as levonorgestrel implants (Norplant). Doxycycline, a drug approved by the Food and Drug Administration (FDA) to treat gum disease, may reduce the occurrence of uterine bleeding and spotting in women who use Norplant. This study will evaluate the effects of doxycycline on uterine bleeding/spotting in women using Norplant.
Status | Recruiting |
Enrollment | 50 |
Est. completion date | February 2005 |
Est. primary completion date | |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Female |
Age group | 18 Years to 40 Years |
Eligibility |
Inclusion Criteria - Regular menstrual periods for the last 2 cycles - Currently not using hormonal contraceptives, including oral contraceptives, patch, ring, or Norplant in 2 months prior to study entry, or Depo-Provera in 12 months prior to study entry - Currently not using tetracycline-class antibiotics - Normal Pap smear Exclusion criteria - Pregnancy or breastfeeding within 2 months of study entry - Chronic migraine headaches - Uncontrolled high blood pressure - Untreated sexually transmitted diseases - Alcoholism or drug abuse within 12 months of study entry - Insulin dependent diabetes - Liver, kidney, or gallbladder disease - Participation in another clinical trial within 30 days of study entry - History of cancer - History of blood clots, strokes, or heart disease |
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Factorial Assignment, Masking: Double-Blind, Primary Purpose: Treatment
Country | Name | City | State |
---|---|---|---|
United States | CONRAD Clinical Research Center, Eastern Virginia Medical School | Norfolk | Virginia |
Lead Sponsor | Collaborator |
---|---|
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) |
United States,
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT02618486 -
The Effects of Obesity on Non Surgical Periodontal Therapy
|
N/A | |
Recruiting |
NCT01785355 -
The Impact Of Periodontal Disease Treatment On The General Health Status In Chronic Haemodialyzed Patients
|
||
Completed |
NCT01639183 -
Power Toothbrush Use in Nursing Homes to Eliminate Mouth and Body Inflammation
|
N/A | |
Completed |
NCT02935322 -
Interaction Between Chlorhexidine and Fluoride
|
Phase 4 | |
Completed |
NCT00093236 -
Impact of Gum Infection on Heart Disease
|
N/A | |
Completed |
NCT03444363 -
Periodontal Treatment With Diode Laser in the Patients With Diabetes Melitus
|
N/A | |
Completed |
NCT03641989 -
Correlation Between Oral Health and Systemic Inflammation (COHESION)
|
N/A | |
Withdrawn |
NCT02202304 -
The Effects of Chlorhexidine/Thymol Varnish on Partial Denture Patient
|
Phase 4 | |
Recruiting |
NCT01568697 -
Oral Bacteria and Immune System Problems Involved in Gum Disease (Periodontitis)
|
||
Completed |
NCT04873505 -
Functional Validation of Lactobacillus Containing Oral Tablet
|
N/A | |
Completed |
NCT01521260 -
Implant Surface Decontamination in Peri-implantitis Treatment
|
N/A | |
Recruiting |
NCT00553007 -
The Relation Between Periodontal Disease and Metabolic Syndrome
|
N/A | |
Completed |
NCT01399034 -
Epigenetics, DNA Methylation Patterns and Periodontal Disease
|
N/A | |
Recruiting |
NCT00162838 -
Effects of Periodontal Pathogens, Porphyromonas Gingivalis and Tannerella Forsythensis, on Cytokine Production From Human Monocyte-Derived Dendritic Cells
|
N/A | |
Completed |
NCT00016835 -
Treating Periodontal Infection: Effects on Glycemic
|
Phase 2 | |
Completed |
NCT03540498 -
Study of Colonization of Strains L.Plantarum and L.Brevis in the Product AB-DENTALAC Chewing Gum
|
N/A | |
Completed |
NCT03775967 -
Estimation of Sialic Acid and IL10 Levels in Stage 1 and 2 Periodontitis Patients
|
||
Completed |
NCT02914743 -
Providing Preventive Periodontal Treatment to Hospitalized Patients With Diabetes
|
N/A | |
Completed |
NCT02894463 -
Study Aimed at Detecting Potential Abuse of Nitrous Oxide in Children During Dental Care
|
N/A | |
Completed |
NCT02289066 -
Impact of Periodontal Disease on Outcomes in Diabetes
|
N/A |