Perinatal Mortality Clinical Trial
Official title:
Machine Learning From Fetal Flow Waveforms to Predict Adverse Perinatal Outcomes
The aim of this study is to get a proof of concept for using a computational model of fetal
haemodynamics, combined with machine learning based on Doppler patterns of the fetal
cardiovascular, cerebral and placental flows, to identify those at increased risk of adverse
perinatal outcomes such as stillbirth, perinatal mortality and other neonatal morbidities.
We will also compare the sensitivity and specificity of UmbiFlow device with the machine
learning model in predicting adverse perinatal outcomes
Status | Not yet recruiting |
Enrollment | 525 |
Est. completion date | December 2018 |
Est. primary completion date | September 2018 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Female |
Age group | N/A and older |
Eligibility |
Inclusion Criteria: - Pregnant woman coming to the ultrasound clinic between 22-34 weeks of gestation. - Written informed consent - Resident of the study area Exclusion Criteria: - Multiple gestation - Known congenital anomaly in the fetus or newborn - Refusal for the ultrasound - Poor echocardiographic images for Doppler acquisition |
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
Aga Khan University | Universitat Pompeu Fabra |
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Stillbirth | Baby born with no signs of life at or after 28 weeks of gestation | At birth | |
Primary | Early neonatal mortality | Death of a baby within the first 7 days of life | Within the first 7 days of life | |
Secondary | IUGR | Fetal weight that is below the 10th percentile for gestational age as determined through an ultrasound | At birth | |
Secondary | Prematurity | Birth of a fetus at < 37 weeks of gestation | At birth | |
Secondary | Birth asphyxia | Delayed cry after at least 1 minute of life | At birth | |
Secondary | Neonatal sepsis | Any 1 of the following danger signs: fever > 38 of < 35.5 C, convulsions, lethargy, poor feeding, chest in drawing and tachypnea (respiratory rate > 60/min) | Within the first 7 days of life | |
Secondary | Low Birth Weight | Birth weight < 2.5 kg | At birth |
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