Perinatal Mortality Clinical Trial
Official title:
Using Verbal Autopsy to Determine Cause of Stillbirths and Early Neonatal Deaths Within the NICHD Global Network
The NICHD Global Network (GN) for Women's and Children's Health Research, a multi-site,
international research network, provides a unique infrastructure to implement an expanded
perinatal verbal autopsy study using the FIRST BREATH trial as its platform. The FIRST
BREATH trial is an ongoing study of neonatal resuscitation training in rural community
settings within Global Network sites in Central Africa, Asia and Latin America.
This study uses a validated VA questionnaire to determine COD of stillbirths and early
neonatal deaths among participants in the FIRST BREATH study. We propose to expand the
usefulness of perinatal verbal autopsy methodology in two ways. First by assessing whether
the Community Coordinator (a non-physician health worker) can assign COD with a high level
of concordance comparable to a Physician Panel, and second, whether the FIRST BREATH Birth
Attendant can provide as reliable perinatal information as the mother during the VA
interview. Our primary hypothesis is that the COD assigned by the FIRST BREATH Community
Coordinator will be the same as the COD assigned by the Physician Panel in greater than 70%
of early neonatal deaths (ENDs), when both use the same VA and FIRST BREATH data.
n/a
Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Double Blind (Subject, Caregiver), Primary Purpose: Diagnostic
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT01945931 -
Evaluation of a Smartphone Application to Reduce Adverse Pregnancy Outcomes in Ethiopia
|
N/A | |
Completed |
NCT01681017 -
Global Network Implementation of Helping Babies Breathe (HBB)
|
N/A | |
Completed |
NCT03590483 -
Outcomes in Spontaneous and ART Twin Pregnancies
|
||
Completed |
NCT00133744 -
Impact of Prenatal Vitamin/Mineral Supplements on Perinatal Mortality
|
Phase 3 | |
Completed |
NCT01115478 -
Malaria in Pregnancy: Nutrition and Immunologic Effects
|
N/A | |
Terminated |
NCT00536003 -
Vaginal Progesterone to Prevent Preterm Delivery in Women With Preterm Labor
|
Phase 3 | |
Completed |
NCT03656237 -
Low-dose High-frequency Training of Facility Health Care Providers in Mali
|
N/A | |
Completed |
NCT00860470 -
Antenatal Micronutrient Supplementation and Infant Survival
|
Phase 3 | |
Completed |
NCT02189265 -
Assessing the Impact of Smoke-free Legislation on Perinatal Health in the Netherlands
|
N/A | |
Completed |
NCT04663620 -
Saving Babies Lives
|
N/A | |
Recruiting |
NCT03108404 -
Predictive Score for Neonatal Mortality for Women With Premature Rupture of Membranes Between 22 and 28 Weeks of Gestation
|
N/A | |
Not yet recruiting |
NCT03398551 -
Machine Learning From Fetal Flow Waveforms to Predict Adverse Perinatal Outcomes
|
N/A |