Myo-inositol Plus Melatonin in Perimenopausal Women

Status Recruiting

Clinical Trial Summary

Menopause is the milestone of a more broaden condition that can last up to 10 years. The first menopausal symptoms usually appear around the age of 42 and are characterized by a gradual decline in thyroid and gonadal function with a progressive increase of plasmatic luteinizing hormone (LH) and follicle stimulating hormone (FSH) levels.

Recent studies have shown that myo-inositol and melatonin play a major role in ovarian homeostasis. In particular, it has been demonstrated that myo-inositol and/or melatonin supplementation lead to an increase of oocyte quality.

Additional studies focused on postmenopausal women have shown that myo-inositol is able to ameliorate the metabolic syndrome that often affects these patients, thus reducing the risk of cardiovascular diseases (CVDs).

The aim of the present study is to evaluate whether myo-inositol and melatonin might play a positive role in regulating hormonal levels during menopausal onset.

Clinical Trial Description

n/a

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Prevention

Related Conditions & MeSH terms

Perimenopause

Clinical Trial Details

NCT number	NCT01325389
Study type	Interventional
Source	AGUNCO Obstetrics and Gynecology Centre
Contact
Status	Recruiting
Phase	N/A

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT01933204` - Acupuncture for Relieving Perimenopausal Symptoms	Phase 2/Phase 3
Unknown status	`NCT02423694` - Effectiveness and Safety of Electro-acupuncture for Mild-to-moderate Perimenopausal Depression	N/A
Recruiting	`NCT03505905` - A Neurosteroid Intervention for Menopausal and Perimenopausal Depression	Phase 1/Phase 2
Completed	`NCT01308814` - Perimenopausal Estrogen Replacement Therapy Study	Phase 2/Phase 3
Recruiting	`NCT04255160` - Impact of Estradiol on Endothelial Function in Peri-Menopausal Women	Phase 4
Completed	`NCT00471731` - Dry Eye in Women With Turner Syndrome and Women With Premature Ovarian Failure	N/A
Not yet recruiting	`NCT06376812` - No Time to Pause: Physical Activity to Improve Health of Midlife Hispanic Women	N/A
Completed	`NCT02779582` - Oral Micronized Progesterone Effects on Perimenopausal Menstrual Flow	Phase 3
Recruiting	`NCT04922385` - Cognitive Behavioural Therapy for Sexual Concerns During Perimenopause	N/A
Completed	`NCT05234814` - Fire Dragon Pot Moxibustion	N/A
Completed	`NCT06018740` - A Study to Examine the Effects of a Daily Supplement on Common Symptoms of Perimenopause and Menopause	N/A
Recruiting	`NCT01414530` - Oral Contraceptive During Menopausal Transition	N/A