Monitoring of Non-Surgical Treatment of Peri-implantitis

Peri-Implantitis Clinical Trial

Official title:

Monitoring of Non-Surgical Treatment of Peri-implantitis, Traditional Measurement Methods and aMMP-8 Test Technology-Cross Sectional Study

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT06408467
• Other study ID #: Lahanna
• Status: Completed
• Phase: N/A
• Start date: January 1, 2022
• Est. completion date: November 15, 2022

Study information

• Verified date: May 2024
• Source: Lahanna oy
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This study aimed to investigate the response to non-surgical treatment of peri-implantitis diseases during the maintenance phase. The patients underwent non-surgical implant maintenance treatment, and the success of the treatment was measured again after 30 days using the same criteria and methods.

Description:

For 40 patients, the aMMP-8 test was performed on the buccal gingival pocket of the implant teeth, gingival bleeding (BOP), implant pocket depth (PPD), and a periapical x-ray to measure radiologic bone level (RBL) were taken.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 40
• Est. completion date: November 15, 2022
• Est. primary completion date: July 1, 2022
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 25 Years and older

Eligibility

Inclusion Criteria:

• implant patients arriving for a maintenance visit at a dental clinic

• a diagnosis of peri-implant healthy, peri-implant mucositis, or peri-implantitis by a dentist

• a written informed consent.

Exclusion Criteria

• Smoking

• age under 25

• antibiotic treatment within six months

• the maintenance treatment had been completed within 6 months.

Related Conditions & MeSH terms

• Mucositis
• Peri-implant Mucositis
• Peri-Implantitis

Intervention

Other:
• aMMP-8 diagnostic test
40 patients

Locations

Country	Name	City	State
Finland	University of Helsinki	Helsinki

Sponsors (2)

Lead Sponsor	Collaborator
Lahanna oy	University of Helsinki

Country where clinical trial is conducted

Finland, 

References & Publications (4)

Alassy H, Parachuru P, Wolff L. Peri-Implantitis Diagnosis and Prognosis Using Biomarkers in Peri-Implant Crevicular Fluid: A Narrative Review. Diagnostics (Basel). 2019 Dec 7;9(4):214. doi: 10.3390/diagnostics9040214. — View Citation

Figuero E, Graziani F, Sanz I, Herrera D, Sanz M. Management of peri-implant mucositis and peri-implantitis. Periodontol 2000. 2014 Oct;66(1):255-73. doi: 10.1111/prd.12049. — View Citation

Lahteenmaki H, Umeizudike KA, Heikkinen AM, Raisanen IT, Rathnayake N, Johannsen G, Tervahartiala T, Nwhator SO, Sorsa T. aMMP-8 Point-of-Care/Chairside Oral Fluid Technology as a Rapid, Non-Invasive Tool for Periodontitis and Peri-Implantitis Screening i — View Citation

Lindhe J, Meyle J; Group D of European Workshop on Periodontology. Peri-implant diseases: Consensus Report of the Sixth European Workshop on Periodontology. J Clin Periodontol. 2008 Sep;35(8 Suppl):282-5. doi: 10.1111/j.1600-051X.2008.01283.x. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	the result of the participants who were measured aMMP-8	Measure aMMP-8-level ng/ml	1 month
Primary	the result of the participants who were measured BOP	measure bleeding on probing in PISF	1 month
Primary	the result of the participants who were measured PPD	measure peri-implant pocket depth	1 month