Regenerative Treatment of Peri-implantitis

Status Enrolling by invitation

Clinical Trial Summary

The purpose of this study is to study the use of a new type of d-PTFE membrane called reinforced PTFE Mesh (RPM) with dental surgery. The regenerative outcomes of RPM membranes and collagen membrane for surgical reconstructive treatment of peri-implantitis (gum disease around implants) will be compared.

Clinical Trial Description

Peri-implantitis is an inflammatory response that leads to irreversible loss of implant supporting bone. This study will investigate the regenerative outcomes obtained with two membranes for surgical reconstructive treatment of peri-implantitis defects when the implant is submerged and primary wound closure is obtained. In one group the newly designed d-PTFE membrane with macropores, known as the RPM membrane will be utilized, which will be compared to the traditional collagen membrane used in the other group. The clinical, radiographic, and histologic outcomes for the regenerative treatment of peri-implantitis when utilizing the same bone graft in combination with either a collagen membrane or the RPM will be evaluated via a parallel-arm randomized controlled clinical trial. 32 patients with peri-implantitis will be recruited and randomized to receive peri-implantitis treatment with either a collagen membrane or an RPM membrane. ;

Study Design

Related Conditions & MeSH terms

Peri-Implantitis

Clinical Trial Details

NCT number	NCT06153212
Study type	Interventional
Source	University of Michigan
Contact
Status	Enrolling by invitation
Phase	N/A
Start date	November 2, 2023
Completion date	December 1, 2025

View Details

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