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NCT05325918 Clinical Trial

HIF-1 Alpha, VEGF and MMP-8 Levels in PICF of Smokers Versus Non Smokers

Peri-Implantitis Clinical Trial

Official title:
HIF-1 Alpha, VEGF and MMP-8 Levels in Peri-implant Crevicular Fluid of Smokers Versus Non Smokers

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT05325918
Other study ID # FUE13
Secondary ID
Status Completed
Phase
First received
Last updated
Start date August 29, 2021
Est. completion date January 30, 2022

Study information
Verified date April 2022
Source Future University in Egypt
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Smoking is a major risk factor for developing peri-implantitis so the current study is comparing inflammatory markers in smokers versus non smokers to know if they have a potential role in pathogenesis of peri-implantitis

Description:

Peri -implant crevicular fluid was obtained from seven smoker patients and then compared to peri-implant crevicular fluid from seven non smoker individuals. The peri-implant crevicular fluid was obtained using periopaper strips then analyzed using ELISA kits of these markers; HIF-1 Alpha, VEGF and MMP-8

Recruitment information / eligibility
Status Completed
Enrollment 14
Est. completion date January 30, 2022
Est. primary completion date January 15, 2022
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 20 Years to 50 Years
Eligibility Inclusion Criteria: - Medically free patients - Individuals with restored implants placed one year or more before study enrollment - Both genders - Age range 20-50 years old Exclusion Criteria: - Pregnant Females - Lactating females

Study Design

Related Conditions & MeSH terms

Locations
Country Name City State
Egypt Faculty of oral and dental medicine,FUE, Cairo,Egypt Cairo

Sponsors (1)
Lead Sponsor Collaborator
Future University in Egypt

Country where clinical trial is conducted

Egypt, 

Outcome
Type Measure Description Time frame Safety issue
Primary Measurement of levels of HIF-1 Alpha, VEGF and MMP-8 in peri-implant crevicular fluid Markers collected using periopaper strips Baseline
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