Laser-Assisted Regenerative Surgical Therapy for Peri-implantitis

Status Completed

Clinical Trial Summary

The purpose of the study is to evaluate if using Erbium-doped yttrium aluminium garnet laser, Erbium YAG laser (Er:YAG) laser could have adjunctive benefits to the conventional standard mechanical debridement to ablate the infected tissue around the dental implant and detoxify the contaminated implant surface for resolving peri-implant infection and enhance bone regeneration of peri-implant defects.

Clinical Trial Description

The purpose of the study is to evaluate if using Er:YAG laser could have adjunctive benefits to the conventional standard mechanical debridement to ablate the infected tissue around the dental implant and detoxify the contaminated implant surface for resolving peri-implant infection and enhance bone regeneration of peri-implant defects.

This study involves one center and a double-blinded randomized controlled clinical trial is planned. Twenty-four adult patients in the need of surgical treatment due to peri-implantitis will be included. Six visits are needed for each patient including a 24 week follow-up visit.

Specific Aim 1: To compare the clinical benefit of Er:YAG laser-assisted peri-implant defect debridement and surface detoxification with conventional mechanical debridement for regenerative therapy

Specific Aim 2: To evaluate whether Er:YAG laser-assisted regenerative surgical therapy can decrease bacterial load and alter microbial profile

Specific Aim 3: To analyze whether Er:YAG laser-assisted regenerative surgical therapy can impact the molecular profile of the peri-implant crevicular fluid (PICF) and the stability of the treatment ;

Study Design

Related Conditions & MeSH terms

Peri-Implantitis

Clinical Trial Details

NCT number	NCT03127228
Study type	Interventional
Source	University of Michigan
Contact
Status	Completed
Phase	N/A
Start date	June 26, 2017
Completion date	November 2, 2018

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT05332327` - Comparison of the Accuracy of Different Periodontal Probes for Peri-implant Pocket Registration
Enrolling by invitation	`NCT06063876` - Experimental Peri-implant Mucositis on Implant Sites That Were Previously Treated With or Without Implantoplasty	N/A
Completed	`NCT04249024` - Peri-implantitis, Comparing Treatments 970 nm Laser and Mucosal Flap Surgery	N/A
Withdrawn	`NCT03624257` - Comparing Two Treatment Modalities of Peri-implantitis - Blue Laser (445 nm) and Conventional Flap Surgery	N/A
Completed	`NCT03157193` - Effect of Hyaluronic Acid on Perimplantitis	Phase 4
Completed	`NCT03018795` - Ozone Therapy as an Adjunct to the Surgical Treatment of Peri-implantitis	N/A
Completed	`NCT02375750` - Treatment of Peri-implantitis Lesions by Using Biomaterial	N/A
Enrolling by invitation	`NCT02575274` - Peri-Implantitis Surgical Treatment an RCT Study	Phase 2/Phase 3
Completed	`NCT04833569` - ICG-PDT, Periimplantitis, Diabetes Mellitus	Phase 1
Not yet recruiting	`NCT04337645` - Resective Surgical Treatment of Peri-implantitis.	N/A
Enrolling by invitation	`NCT06033859` - Incidence of Bleeding on Probing as an Indicator of Peri-Implant Disease Progression
Active, not recruiting	`NCT06390124` - Reconstructive Therapy of Peri-implantitis With PDGF-BB (Gem-21)	Phase 4
Enrolling by invitation	`NCT05675241` - Characterizing the Inflammation Around Dental Implants
Recruiting	`NCT04983758` - 20-year Implant Survival in Periodontally Healthy and Compromised Patients
Not yet recruiting	`NCT04323540` - Treatment of Peri-implantitis With or Without Simultaneous Soft Tissue Augmentation	N/A
Completed	`NCT04769609` - Reconstructive Surgical Therapy of Peri-implantitis
Completed	`NCT04874467` - Influence of Keratinized Mucosa on Dental Implants With Mucositis	N/A
Completed	`NCT05724706` - An Evaluation of Salivary Oxidant and Antioxidant Levels in Peri-implant Health and Disease
Completed	`NCT04559841` - Regenerative Surgical Treatment of Peri-implantitis Using Nanobone With or Without Simvastatin	N/A
Recruiting	`NCT05906810` - Impact of Non-surgical Periodontal Therapy in the Improvement of Early Endothelial Dysfunction in Subjects With Peri-implantitis and Peri-implant Mucositis	N/A