Influence of Sodium Bicarbonate on Time-to-exhaustion at Critical Power in Endurance Athletes

Performance Clinical Trial

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01621074
• Other study ID #: nbc
• Status: Completed
• Phase: N/A
• First received: June 12, 2012
• Last updated: April 11, 2013
• Start date: October 2011
• Est. completion date: January 2013

Study information

• Verified date: April 2013
• Source: University of Zurich
• Contact: n/a
• Is FDA regulated: No
• Health authority: Switzerland: Ethikkommission
• Study type: Interventional

Clinical Trial Summary

During endurance exercise in the heavy and severe intensity domains, the rate at which metabolites that have been associated with the fatigue process (e.g. Pi, ADP, H, and extracellular K) accumulate increases. possibly leading to exercise cessation. Sodium bicarbonate, as a nutritional supplement, has gained attention over the past decades, because it might delay of offset fatigue. To date, there is a controversial discussion about which delivery mode (amount and frequency) might be best in optimizing endurance performance. Since the high ion load consequent to multiple ingestions might increase plasma volume, and consequently decrease bicarbonate concentrations, single acute ingestion could be more beneficial. However, in multi-day competitions or tournaments it might be necessary to use the supplement on a daily basis. Here, the investigators aim at investigating the effects of single dose or multiple dose (on five consecutive days) administration of bicarbonate vs. placebo increases endurance performance and acid-base homeostasis in trained male endurance athletes.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 12
• Est. completion date: January 2013
• Est. primary completion date: August 2012
• Accepts healthy volunteers: No
• Gender: Male
• Age group: 18 Years to 45 Years

Eligibility

Inclusion criteria: - male

• no cold or temperature at beginning or during the study

• between 18 and 45 years of age

• active in endurance sports (3 to 5 times per week a moderate to hart training)

• non-smoker

• no known cardiovascular or orthopedic problems

• no known limitations of kidney function

• no bearer of a cardiac pacemaker

• no medications with direct influence on the measurements. The whole intake of medicaments has to be declared in the health questionnaire by the participant.

• requirements of the health questionnaire fulfilled

Exclusion criteria: - female

• male and age under 18 or over 45 years

• cold or temperature at the beginning or during the study

• untrained (less than 3 moderate trainings per week)

• smoker

• cardiovascular or orthopedic problems

• limitations of the kidney function

• bearer of a cardiac pacemaker

• medication with direct influence on the measurements. The whole intake of medicaments has to be declared in the health questionnaire by the participant.

• requirements of the health questionnaire not fulfilled

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Outcomes Assessor)

Related Conditions & MeSH terms

• Performance

Intervention

Dietary Supplement:
• Sodium bicarbonate
Ergogenic effect
• Placebo
Placebo effect

Locations

Country	Name	City	State
Switzerland	University Hospital Zurich, Division of Neurology	Zurich	ZH

Sponsors (2)

Lead Sponsor	Collaborator
University of Zurich	Swiss Federal Institute of Technology

Country where clinical trial is conducted

Switzerland, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Time-to-exhaustion		5 weeks	No