Perennial Rhinitis Clinical Trial
Official title:
Local IgE in Subjects With Allergic or Non-allergic Rhinitis
The purpose of the study is to investigate the incidence of non-allergic rhinitis on a not selected group of young students (n=100-300). Students will be selected by public posting. In all students an allergy skin test will be performed. Then the local IgE of 24 subjects with non-allergic rhinitis will be compared to the local IgE of 24 subjects with allergic rhinitis and positive prick test to house dust mite. In addition 20 controlls will be investigated. Based on these investigations, the importance of local IgE and the IgE spectrum in conjunction with rhinitis should be further clarified.
20% of Germans suffer from seasonal or all-season rhinitis. Despite typical allergic
symptoms, in a part of the affected patients (about 10-20%) an allergy cannot be found on
skin prick test or blood. Therefore, the planned trial will investigate the incidence of
allergic and non-allergic rhinitis in a non selected group of young students (n=100-300). The
hypothesis postulates that in test subjects with non-allergic rhinitis the allergy can only
be proven locally in nasal secretion.
From the initial large cohort of patients, 24 subjects with house dust mite allergy and
allergic rhinitis and 24 patients with non-allergic rhinitis will be selected and
investigated in more detail at a second visit. At the second visit, blood and nasal secretion
(measurement of local IgE) will be taken from all pre-selected 48 patients. At visit 2 a
nasal provocation test with house dust mite allergen will be performed in all patients to
compare nasal symptoms with the results of local IgE between patient groups. In addition the
same investigations will be performed in a group of 20 healthy non-allergic subjects.
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| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT01369563 -
Efficacy, Safety & Tolerability of Ciclesonide 200mcg Spray 4 Weeks Treatment for Intermittent & Persistent Rhinitis
|
N/A |