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Efficacy of H2 Receptor Antagonist in Prevention of Thienopyridine-related Peptic Ulcer

Peptic Ulcer Clinical Trial

Official title:
Efficacy of H2 Receptor Antagonist in Prevention of Thienopyridine-related Peptic Ulcer

Clinical Trial Summary

Whether H2 receptor antagonist can prevent thienopyridine-related peptic ulcer remains unclear.

Clinical Trial Description

The aim of the prospective, randomized study is investigate the efficacy of H2 receptor antagonist in prevention of thienopyridine-related peptic ulcer and gastrointestinal bleeding in patients with an ulcer history. We plan to enroll 236 thienopyridine (clopidogrel or ticlopidine) users with a peptic ulcer history who don't have baseline gastroduodenal ulcers at initial endoscopy . The patients will be randomly assigned to receive either (1) famotidine (40 mg qd) plus thienopyridine used previously or (2) placebo plus thienopyridine treatment alone for 6 months. The ulcer recurrence rate between the treatment gruops will be compared. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02418312
Study type Interventional
Source Kaohsiung Veterans General Hospital.
Contact
Status Completed
Phase N/A
Start date January 2012
Completion date October 2017
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