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Peptic Ulcer Hemorrhage clinical trials

View clinical trials related to Peptic Ulcer Hemorrhage.

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NCT ID: NCT00519519 Completed - Clinical trials for Bleeding Peptic Ulcers Disease

Optimal Dose of Omeprazole After Endoscopic Treatment of Bleeding Peptic Ulcers

Start date: July 2004
Phase: Phase 3
Study type: Interventional

Bleeding peptic ulcers are one of the major causes of morbidity and mortality for hospital emergency admissions.The initial treatment is endoscopic therapy followed by intravenous omeprazole. However the optimal dosage of omeprazole is not known. We conducted this study to find out the optimal dosage in such clinical scenario.

NCT ID: NCT00279123 Completed - Clinical trials for Peptic Ulcer Hemorrhage

Effects of 2 Different Doses of Pantoprazole on Gastric pH and Recurrent Bleeding in Patients Who Bled From Peptic Ulcers

Start date: January 2002
Phase: Phase 4
Study type: Interventional

Endoscopic treatment of bleeding peptic ulcers is effective to prevent rebleeding. Adjuvant medical treatment to increase gastric pH may further decrease rebleeding. Recent studies on potent acid suppression by proton pump inhibitors (PPI) demonstrated the efficacy in preventing rebleeding. Lau demonstrated that high dose intravenous infusion of omeprazole decreased rebleeding in peptic ulcers with stigmata of recent hemorrhage. There is little data regarding the effect of pantoprazole on bleeding peptic ulcers. Furthermore, the optimal dose of PPI is unknown. Few studies have included measurement of gastric pH in addition to clinical outcome. This study compares the effect of two doses of intravenous pantoprazole with no acid suppression in bleeding peptic ulcers after endoscopic therapy. In addition to the usual clinical endpoints, gastric pH is monitored to study the relation of pH elevation and the clinical outcome.

NCT ID: NCT00251979 Completed - Clinical trials for Gastrointestinal Hemorrhage

A Study to Prevent Rebleeding After Initial Successful Primary Endoscopic Haemostasis of a Bleeding Peptic Ulcer

Start date: October 2005
Phase: Phase 3
Study type: Interventional

This study is being carried out to see if constant 3 days infusion of Nexium is effective in preventing rebleeding after an endoscopic treatment.

NCT ID: NCT00165009 Terminated - Clinical trials for Peptic Ulcer Hemorrhage

Resolution Endoclips Vs Epinephrine Injection and Heater Probe

Start date: June 2005
Phase: Phase 3
Study type: Interventional

To compare the efficacy of a novel endoscopic clipping device(Resolution Clip™) and conventional epinephrine injection and heater probe thermocoagulation in control of peptic ulcer bleeding and prevention of recurrent bleeding

NCT ID: NCT00164931 Completed - Clinical trials for Peptic Ulcer Hemorrhage

A Study Comparing High Dose Omeprazole Infusion Against Scheduled Second Endoscopy for Bleeding Peptic Ulcer

Start date: October 2003
Phase: Phase 3
Study type: Interventional

A prospective randomized study to compare the adjunctive use of high dose omeprazole infusion against scheduled second endoscopy in prevention of peptic ulcer rebleeding after therapeutic endoscopy.

NCT ID: NCT00164905 Terminated - Clinical trials for Peptic Ulcer Hemorrhage

Role of Doppler Ultrasound in Severe Peptic Ulcer Hemorrhage

Start date: September 2004
Phase: N/A
Study type: Interventional

The aim of study is to evaluate whether Doppler ultrasound can accurately identify patients who are at risk of recurrent bleeding, who will require endoscopic therapy, and who will fail endoscopic therapy.

NCT ID: NCT00164827 Recruiting - Clinical trials for Bleeding Peptic Ulcer

Surveillance of Bleeding Peptic Ulcer Using Wireless Capsule Endoscopy

Start date: January 2003
Phase: Phase 3
Study type: Observational

To investigate the adjunctive role of “Capsule Endoscope” in continuous endoscopic monitoring and early detection of recurrent ulcer bleeding after endoscopic therapy in patients presenting with bleeding peptic ulcers

NCT ID: NCT00153712 Completed - Peptic Ulcer Clinical Trials

Natural History of Non-steroidal Anti-inflammatory Drug and Non-Helicobacter Pylori in Bleeding Peptic Ulcers

Start date: August 2002
Phase: N/A
Study type: Observational

The aim of this study is to study the natural history of the ulcer healing while on proton pump inhibitors (PPI) and the ulcer recurrence without acid suppression therapy of Non-steroidal Anti-inflammatory Drugs (NSAID), non-Helicobacter pylori (HP) bleeding ulcer patients.

NCT ID: NCT00152399 Completed - Peptic Ulcer Clinical Trials

Study to Assess the Efficacy and Safety of Somatostatin in the Treatment of Acute Severe Upper Gastrointestinal Bleeding

Start date: September 2000
Phase: Phase 2
Study type: Interventional

To assess the efficacy and safety of the early administration of somatostatin in infusion during 72 hours plus 2 boluses, compared to placebo in the control of acute severe UGIB with suspicion of PUB.

NCT ID: NCT00040495 Completed - Clinical trials for Peptic Ulcer Hemorrhage

Study Evaluating Pantoprazole in Peptic Ulcer Hemorrhage

Start date: April 2001
Phase: Phase 3
Study type: Interventional

The purpose of this study is to evaluate the efficacy and safety of intravenous pantoprazole in the prevention of rebleeding in patients with bleeding peptic ulcer disease after successful endoscopic hemostatic therapy.