Peptic Ulcer/Erosions Clinical Trial
Official title:
Famotidine vs. Pantoprazole to Prevent Recurrent Aspirin-Induced Peptic Ulcer/Erosion - a Randomized Controlled Study
Low-dose aspirin can prevent cerebral and cardiovascular accidents in individuals with
symptomatic atherothrombotic disease, but its use is frequently limited by gastrointestinal
side effects.
The position of H2-receptor antagonists as a step-down therapy after healing of peptic ulcer
or erosions by proton pump inhibitor is unclear.
The objective of this randomized, double blinded control study was to compare the efficacy
of high-dose famotidine with pantoprazole in the prevention of recurrent dyspeptic or
complicated ulcer/ erosions in patients taking low-dose aspirin
Low-dose aspirin can prevent cerebral and cardiovascular accidents in individuals with
symptomatic atherothrombotic disease . Its use is frequently limited by gastrointestinal
side effects, ranging from dyspepsia (31%) to life-threatening bleeding or perforation of
gastroduodenal ulcers (3.1%) over a period of 4 years .
The best approach for the secondary prevention of low-dose aspirin induced symptomatic
peptic ulcer or erosions in patients who need to continue aspirin remain uncertain. At
present, eradication of Helicobacter pylori infection and long-term maintenance with proton
pump inhibitor PPI appears to be the best options.
The position of H2-receptor antagonists (H2RA) as a step-down therapy after healing of
peptic ulcer or erosions is unclear.
The objective of this randomized, double blinded control study was to compare the efficacy
of high-dose famotidine with pantoprazole in the prevention of recurrent dyspeptic or
complicated ulcer/ erosions in patients taking low-dose aspirin.
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Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Prevention