Clinical Trials Logo

Clinical Trial Summary

The primary objective of the study is to evaluate the equivalency of the skin test reactivity to penicilloate prepared by our new method of penicilloate preparation versus our old method of penicilloate preparation. The secondary objective of the study is to evaluate the significance of the different diastereoisomers of penicilloate on skin test reactivity.


Clinical Trial Description

The primary objective of the study is to evaluate the equivalency of the skin test reactivity to penicilloate prepared by our new method of penicilloate preparation versus our old method of penicilloate preparation. The secondary objective of the study is to evaluate the significance of the different diastereoisomers of penicilloate on skin test reactivity.

Five (5) adult subjects without a history of penicillin allergy and fifteen (15) adult subjects with a history of penicillin allergy and previous positive penicillin skin test to the minor determinant (penicilloate) and/or major determinant (penicilloyl) will be enrolled into the study. Each subject will be skin tested with our current penicillin skin test which includes penicilloate conducted in the Division of Allergic Diseases will be compared the skin test of our penicilloate prepared by our newer method along with the different diastereoisomers of penicilloic acid on the same day and time. The adult subjects without a history of penicillin allergy will serve as our control. ;


Study Design

Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic


Related Conditions & MeSH terms


NCT number NCT00589251
Study type Interventional
Source Mayo Clinic
Contact
Status Withdrawn
Phase N/A
Start date June 2008
Completion date May 2010

See also
  Status Clinical Trial Phase
Terminated NCT05563610 - Oral Penicillin Challenge and Allergy De-labeling in Children Phase 4
Completed NCT05020327 - Inpatient Penicillin Allergy Delabeling Study Phase 4
Completed NCT04441021 - Feasibility Assessment of Risk Stratification and Oral Challenge in Hospitalized Children at Low Risk for Antibiotic Allergy
Not yet recruiting NCT05956080 - Penicillin Allergy Delabeling Among Surgical Patients N/A
Recruiting NCT03757052 - Amoxicillin Challenge for Penicillin Allergy Diagnosis N/A
Completed NCT03702270 - The Effect of Providing Stratification of Low Risk Penicillin Allergies on Penicillin Allergy Label Removal N/A
Recruiting NCT05464615 - Geisinger Antibiotic Allergy Pilot Program: Assess and Address Early Phase 1
Completed NCT03702283 - Effect of Providing Stratification of Low Risk Penicillin Allergies on Penicillin Allergy Label Removal in ICU Setting N/A
Not yet recruiting NCT03499457 - Penicillin Allergy in Shfayim Clinic N/A
Completed NCT01667055 - The Diagnosis of Beta-lactam Hypersensitivity in Thailand
Completed NCT04620746 - Penicillin Allergy Testing in STD Clinics Phase 4
Completed NCT05090527 - Penicillin Allergy Delabeling Project N/A
Completed NCT03033394 - Beta-lactam Pharmacokinetics in Secondary Care
Completed NCT02036840 - Perioperative Antibiotic Choices for Surgical Prophylaxis in Penicillin-allergic Pediatric Patients N/A
Terminated NCT00363688 - Treating Patients With a History of Non-Life Threatening Allergic Reaction to Penicillin With Penicillin Phase 4
Completed NCT03158831 - Drug Challenges Without Prior Skin Testing Phase 1
Recruiting NCT06303128 - Penicillin Allergy Delabeling After a One-Dose Versus Two-Dose Graded Direct Oral Challenge Phase 3
Completed NCT03942731 - Penicillin Allergy Testing and Resensitization Rate
Completed NCT05010304 - Penicillin De-labeling in the Pediatric Primary Care Setting Phase 4
Completed NCT03404804 - Oral Challenge in the Pediatric ED Phase 4