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Clinical Trial Summary

Pemphigus vulgaris (PV) is a rare, chronic, debilitating, and potentially life-threatening autoimmune disorder that is characterized by mucocutaneous blisters.Abatacept is a biologic drug that belongs to the class of T-cell co-stimulation modulators and is used for the treatment of autoimmune diseases.


Clinical Trial Description

The background therapy is based on prednisolone administration. PV is a rare disorder, therefore this study is designed as a crossover that may require fewer patients than a parallel study. The study enrolled participants with moderate-to-severely active PV requiring ≥ 50 milligrams per day (mg/day) oral prednisone or equivalent. The purpose of this study was to evaluate the efficacy, tolerability, and safety of abatacept injection for subcutaneous use (abatacept SC) 150 mg administered once in a week in subjects with PV. It was anticipated that with sustained immune suppression in the presence of abatacept SC that clinical remission of the disease would be improved. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05303272
Study type Interventional
Source Tongji Hospital
Contact YIKAI YU
Phone +1 484-995-5917
Email yuyikai@163.com
Status Recruiting
Phase Phase 4
Start date February 1, 2021
Completion date September 30, 2022

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