Clinical Trial Details
— Status: Not yet recruiting
Administrative data
| NCT number |
NCT06146400 |
| Other study ID # |
pediatric pneumonia |
| Secondary ID |
|
| Status |
Not yet recruiting |
| Phase |
|
| First received |
|
| Last updated |
|
| Start date |
December 2023 |
| Est. completion date |
February 2024 |
Study information
| Verified date |
November 2023 |
| Source |
Assiut University |
| Contact |
Amera A. Saber, Researcher |
| Phone |
01027743031 |
| Email |
merhelsherif51[@]gmail.com |
| Is FDA regulated |
No |
| Health authority |
|
| Study type |
Observational
|
Clinical Trial Summary
Detection of the role of Complete Blood Count (CBC) parameters in early diagnosis of
pediatric pneumonia
-Testing the ability of Complete Blood Count (CBC) parameters (N/L ratio, PLT /MPV ratio, MPV
and other parameters) to differentiate between viral and bacterial pneumonia.
Description:
Pneumonia is the leading cause of hospitalizations and death among children with nearly 120
million new cases and one million deaths every year.
- Viruses are the main cause of pneumonia in infants and toddlers between 30 days and 2
years old.
- Children 2 to 5 years old, respiratory viruses are also common with the rise of cases
related to S. pneumoniae and H. influenzae type B and other bacterial organisms.
Viral pneumonia caused by , respiratory syncytial virus, which are the most common cause of
community- acquired pneumonia in children younger than 5 years. Streptococcus pneumoniae is
the most common bacterial cause across all age groups. Other important bacterial causes in
children younger than 5 years include Hemophilus influenzae, Streptococcus pyogenes,
Staphylococcus aureus, and Moraxella catarrhalis.
Parapneumonic effusion/empyema (PPE/EP), necrosis of lung parenchyma (NC), and lung abscess
(AB), are serious complication of pediatric pneumonia. Because of these serious
complications, early diagnosis of the causative organism is very important to start the
proper treatment and avoid these serious complications.
Complete Blood Picture (CBC) is one of the most important preliminary routine investigations
for diagnosis and monitoring of infection.
Recently, CBC parameters, especially Total Leucocyte Count (TLC), ANC, and platelet count all
showed significant associations with neonatal sepsis. Besides, the TLC,Absolute neutrophils
count (ANC), and platelet counts had good sensitivity and specificity in diagnosing neonatal
sepsis
Another study have assessed the utility of C-reactive protein (CRP), White Cell Count (WCC),
Neutrophil/Lymphocyte ratio (N/L), Platelets/ Mean Platelets Volume ratio (PLT/MPV ratio),
Mean Platelets Volume (MPV), Monocyte Distribution Width (MDW) and many other CBC ratios to
differentiate probable bacterial infections from non-bacterial infections and also assessed
the severity of illness.
- In this study, we are going to test the role of Complete Blood Picture (CBC) parameters and
ratios as an early detection tool of bacterial and viral pneumonia. This might have a role in
early prediction and diagnosis of the causative organism. Which in turn leads to rapid
intervention, and better prognosis.
