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Clinical Trial Summary

Papillary thyroid cancer (PTC) is a common type of thyroid cancer in children and represents the second most common cancer in adolescent females. Recently targeted drugs that block many of the genetic drivers of PTC have become available. While Investigators know that these drugs shrink PTC tumors in many cases, the impact on radioactive iodine (RAI) avidity has not been systematically studied.

Clinical Trial Description

This is an observational cohort study that will enroll patients with PTC metastatic to the lungs who will receive oncogene-specific targeted therapy as part of routine clinical care. After approximately 1 week of therapy, patients will have a whole body scan to determine the change in RAI-avidity of the tumor from baseline. Subsequent therapy will be at the discretion of the treating physician. ;

Study Design

Related Conditions & MeSH terms

NCT number NCT05024929
Study type Observational
Source Children's Hospital of Philadelphia
Contact Maeda Saboor, MD
Phone 267-426-9343
Email [email protected]
Status Not yet recruiting
Start date October 1, 2021
Completion date February 1, 2033

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