Clinical Trials Logo
  1. Home
  2. Pediatric Brain Tumor
  3. NCT06226519
  4. Details
NCT06226519 Clinical Trial

Integrated PET/MRI and Germline Variants to Differentiate Brain Tumopr Recurrence From Iatrogenicchanges in Children

Pediatric Brain Tumor Clinical Trial

Official title:
Integrated PET/MRI and Germline Variants to Differentiate Brain Tumopr Recurrence From Iatrogenicchanges in Children

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT06226519
Other study ID # PET/RMN
Secondary ID
Status Recruiting
Phase
First received
Last updated
Start date May 13, 2020
Est. completion date May 13, 2024

Study information
Verified date January 2024
Source IRCCS San Raffaele
Contact Arturo Chiti
Phone 0226432716
Email chiti.arturo@hsr.it
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Nuclear magnetic resonance imaging (NMR) is used in pediatric brain tumors for purposes of diagnosis, evaluation of response to treatments, and monitoring of patients in follow-up. Through conventional imaging techniques it remains difficult to differentiate tumor recurrence from pseudo-progression or other iatrogenic changes after radiotherapy or chemotherapy, but it remains a relevant and essential clinical need for patient management.

Recruitment information / eligibility
Status Recruiting
Enrollment 60
Est. completion date May 13, 2024
Est. primary completion date May 13, 2024
Accepts healthy volunteers
Gender All
Age group N/A to 18 Years
Eligibility Inclusion Criteria: - children and/or adolescents (=18 years) diagnosed with brain tumor. - children who underwent the contemporary adjuvant therapy protocol of post-surgical chemo and radiotherapy. Exclusion Criteria: - patients >18 years

Study Design

Related Conditions & MeSH terms

Intervention

Diagnostic Test:
• 11C-MET-PET/RMN
60 children and/or adolescents (=18 years) with a diagnosis of brain tumor (medulloblastoma, other embryonal tumors or high-grade gliomas), who have followed the contemporary adjuvant therapy protocol of post-surgical chemo and radiotherapy and completed radiotherapy for at least 6 months will undergo a brain MET-PET/MRI.

Locations
Country Name City State
Italy Irccs San Raffaele Milano

Sponsors (1)
Lead Sponsor Collaborator
IRCCS San Raffaele

Country where clinical trial is conducted

Italy, 

Outcome
Type Measure Description Time frame Safety issue
Primary MET-PET/brain MRI in children with brain tumor for diagnosis of brain tumor recurrence compared to therapy-induced changes. The role of MET-PET/MRI and radiogenomics could play in the follow-up management of children and adolescents with brain tumors and in ensuring timely intervention in case of tumor recurrence/progression. 4 years
See also
  Status Clinical Trial Phase
Withdrawn NCT03068832 - Neoepitope-based Personalized Vaccine Approach in Pediatric Patients With Recurrent Brain Tumors Phase 1
Terminated NCT03330197 - A Study of Ad-RTS-hIL-12 + Veledimex in Pediatric Subjects With Brain Tumors Including DIPG Phase 1/Phase 2
Active, not recruiting NCT03911388 - HSV G207 in Children With Recurrent or Refractory Cerebellar Brain Tumors Phase 1
Recruiting NCT05367076 - Fitness to Aid the Brain and Cognitive Skills N/A
Completed NCT03615404 - Cytomegalovirus (CMV) RNA-Pulsed Dendritic Cells for Pediatric Patients and Young Adults With WHO Grade IV Glioma, Recurrent Malignant Glioma, or Recurrent Medulloblastoma Phase 1
Completed NCT04351035 - National Wide Cross-sectional Study in Paediatric Central Nervous System Tumours in China -- the CNOG-MC001 Registry
Completed NCT01707836 - Neurofibromatosis Type 1 Brain Tumor Genetic Risk N/A
Withdrawn NCT03577600 - Compassionate Treatment in Children With Brain Tumors With the Cytotron® N/A
Completed NCT04659421 - Study of Recombinant Human Endostatin Combined With CV Regimen in the Treatment of Pediatric Low-grade Gliomas Phase 2
Active, not recruiting NCT03739372 - Clinical Benefit of Using Molecular Profiling to Determine an Individualized Treatment Plan for Patients With High Grade Glioma N/A
Recruiting NCT05887882 - Intra-Tumoral Injections of Natural Killer Cells for Recurrent Malignant Pediatric Brain Tumors Phase 1
Suspended NCT03334162 - Playful Sensorimotor Training in Pediatric Brain Tumor Patients N/A
Withdrawn NCT01861990 - Valproic Acid in Childhood Progressive Brain Tumors Phase 1
Completed NCT04944875 - Effects of Music and Maternal Voice on Sedation Depth and Sedative Use During Pediatric Magnetic Resonance Imaging. N/A
Terminated NCT03591861 - Therapeutic Targeting of Sex Differences in Pediatric Brain Tumor Glycolysis N/A
Completed NCT03434262 - SJDAWN: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors Phase 1
Recruiting NCT04239092 - 9-ING-41 in Pediatric Patients With Refractory Malignancies. Phase 1
Active, not recruiting NCT03208387 - Understanding the Late Effects of Surviving a Pediatric Brain Tumor
Recruiting NCT05528939 - Feasibility/Acceptability of Attentional-Control Training in Survivors N/A
Recruiting NCT05740839 - High-Intensity Interval Exercise in Young Adult Survivors of Pediatric Brain Tumors: A Pilot Feasibility Study N/A