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Pediatric Brain Tumor clinical trials

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NCT ID: NCT04341311 Terminated - Pediatric Cancer Clinical Trials

Phase I Study of Marizomib + Panobinostat for Children With DIPG

DIPG
Start date: August 10, 2020
Phase: Phase 1
Study type: Interventional

This research study is evaluating the safety, tolerability and preliminary efficacy of the drugs marizomib and panobinostat in pediatric patients with diffuse intrinsic pontine glioma (DIPG). The names of the study drugs involved in this study are: - Marizomib - Panobinostat

NCT ID: NCT03591861 Terminated - Clinical trials for Pediatric Brain Tumor

Therapeutic Targeting of Sex Differences in Pediatric Brain Tumor Glycolysis

Start date: May 1, 2019
Phase: N/A
Study type: Interventional

The investigators will develop the concept of a sex-specific therapeutic intervention for gliomas that is based upon dietary carbohydrate restriction. The investigators will integrate metabolomics tools and FDG-PET imaging to validate the ketogenic diet on a sex-specific basis.

NCT ID: NCT03330197 Terminated - Clinical trials for Diffuse Intrinsic Pontine Glioma

A Study of Ad-RTS-hIL-12 + Veledimex in Pediatric Subjects With Brain Tumors Including DIPG

Start date: September 26, 2017
Phase: Phase 1/Phase 2
Study type: Interventional

This research study involves an investigational product: Ad-RTS-hIL-12 given with veledimex for production of human IL-12. IL-12 is a protein that can improve the body's natural response to disease by enhancing the ability of the immune system to kill tumor cells and may interfere with blood flow to the tumor. The main purpose of this study is to evaluate the safety and tolerability of a single tumor injection of Ad-RTS-hIL-12 given with oral veledimex in the pediatric population.