Pediatric Brain Stem Glioma Clinical Trial
Official title:
Prospective Randomized Trial of Hypofractionated Radiotherapy Versus Conventional Radiotherapy in Diffuse Brainstem Glioma in Children.
Hypofractionated radiotherapy reduce the patient and family burden through decreasing the overall treatment time. This study is to evaluate the clinical end results of the hypofractionated radiotherapy in DIPG compared to the conventional treatment. The non-inferiority of the hypofractionated radiotherapy will result in decrease the hospital, stay or engagement, for more than its half with the same results.
In lack of open study protocols aiming to increase cure rate in pediatric diffuse intrinsic
pontine glioma (DIPG), the investigators examined a hypofractionated radiotherapy regimen up
to a dose of 39Gy in 13 fractions, completed in 2.5-3 weeks, instead of 6 weeks.
This schedule offers a reduction in patient burden, especially preferable in children with a
poor compliance and performance status. The non-inferiority of the hypofractionated regimen
in its clinical end-results, with the reduction of the overall treatment time to less than
its half will decrease the burden for the patient, his/her family and the treating
department. This will be considered as added value without compromising the survival or
increasing side effects.
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| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT01878266 -
Prospective Trial of Two Hypofractionated Radiotherapy Regimens Versus Conventional Radiotherapy in Diffuse Brainstem Glioma in Children
|
N/A |