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Clinical Trial Summary

The aim of the current study was to compare the effects of sevoflurane and desflurane on respiratory mechanics in patients undergoing repair of pectus excavatum.


Clinical Trial Description

The minimally invasive technique for pectus excavatum repair was introduced by Nuss and colleagues using a metal bar to lift the depressed chest wall. This surgical procedure is usually done under general anesthesia with tracheal intubation. After inserting metal bar into the chest wall, decreased lung compliance was shown. Previous studies demonstrated that administering desflurane during anesthesia resulted in marked increases in respiratory mechanical parameters, especially in the children with airway susceptibility. Our primary hypothesis was that desflurane would cause an increase in respiratory resistance and a decrease in lung compliance compared to sevoflurane during repair of pectus excavatum. ;


Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject), Primary Purpose: Supportive Care


Related Conditions & MeSH terms


NCT number NCT01486953
Study type Interventional
Source The Catholic University of Korea
Contact Jeong Eun Kim, M.D, Ph.D
Phone 82-2-2258-6163
Email moroo0201@catholic.ac.kr
Status Recruiting
Phase Phase 4
Start date November 2011
Completion date April 2014

See also
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Completed NCT05443113 - Young Pectus Excavatum Patients and Genetic Defects
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Recruiting NCT06110689 - Capturing Physiologic Autonomic Data From Clinically Indicated Magnetic Resonance Imaging Scans in Children
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Completed NCT02169297 - Sub-Paraspinal Block in Nuss Patients. A Pilot Project Phase 4
Completed NCT02174796 - Hemodynamic Repercussions of the Correction (Surgical and Non Surgical) of Pectus Excavatum-type Thoracic Deformities N/A
Recruiting NCT04211935 - Identification of Best Postoperative Analgesia Method Following a Minimally Invasive Repair of Pectus Excavatum N/A
Completed NCT02721017 - Cryoanalgesia vs. Epidural in the Nuss Procedure Phase 4
Completed NCT02337621 - Pain, Exercise and Psychological Well-being in Pectus Excavatum
Terminated NCT01863498 - Prospective Trial: Pain Management After Pectus Excavatum Repair, Epidural Versus PCA N/A
Recruiting NCT04418583 - Quantifying the Effect of the Crane Technique Through Three-dimensional Imaging N/A
Active, not recruiting NCT05063695 - Pectus ESC Outcomes and Comparative Effectiveness Study
Completed NCT01816373 - Non-invasive Negative Pressure Treatment for Pectus Excavatum N/A
Withdrawn NCT02376634 - Hypnotherapy in Major Surgical Procedures N/A
Completed NCT02163265 - Impact of Surgical Treatments of Thoracic Deformation on Cardiopulmonary Functions N/A
Completed NCT02958683 - Chest Wall Motion Analysis in Disease
Not yet recruiting NCT04052321 - Quantification of Chest Wall Changes After Nuss Bar Removal Utilizing Three-dimensional Optical Surface Scans N/A