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Dampening the Reproductive Axis With Continuous Kisspeptin

Polycystic Ovary Syndrome Clinical Trial

Official title:
Dampening the Reproductive Axis With Continuous Kisspeptin

Clinical Trial Summary

The goal of this study is to assess response to kisspeptin as well as the baseline patterns of luteinizing hormone (LH) secretion in individuals with polycystic ovarian syndrome (PCOS).

Clinical Trial Description

Assignment: All study subjects will undergo the same interventions. Baseline LH secretion patterns of individuals with PCOS will be compared to their LH secretion patterns while receiving a kisspeptin infusion. Delivery of Interventions: - Prior to the inpatient study visit, the subjects will undergo a review of their medical history, physical exam, and screening laboratories. - On the day of the study, the subjects will have an intravenous (IV) line placed and - Undergo up to q10 min blood sampling x 36 hours - Receive an infusion of kisspeptin x 24 hours - Receive up to two kisspeptin IV boluses - Receive up to one gonadotropin-releasing hormone (GnRH) IV bolus ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05971849
Study type Interventional
Source Massachusetts General Hospital
Contact Study Coordinator
Phone 617-643-2308
Email MGHKisspeptinResearch@partners.org
Status Recruiting
Phase Phase 1
Start date October 6, 2023
Completion date December 31, 2023
View Details
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