PCOS Clinical Trial - Bisphenol Role in the Pathogenesis of PCOS

Status Completed

Clinical Trial Summary

Polycystic ovary syndrome (PCOS) is the most common and the most heterogeneous endocrine disorder in premenopausal women. Its prevalence is estimated from 5 to 10% depending on the diagnosis' criteria . Apart from signs of hyperandrogenism such as acne, hirsutism and hair loss; women with PCOS usually present with menstrual irregularities and fertility problems ..

Clinical Trial Description

Bisphenol A is formed from acetone and phenol, it is used in production of epoxy resin, polyster resins and polyvarbonate resins. Epoxy resins are used in plastics, adhesives, and structural composites . Humans are at the end of the food chain, thus they are exposed to the highest doses of these compounds. EDs have been detected in human adipose tissue and biological fluids such as: serum, urine, milk and amniotic fluid . Additionally, it has been proven that BPA can also directly stimulate androgen synthesis in the ovarian theca-interstitial cells. A correlation between increased serum testosterone levels observed in women with PCOS with serum BPA concentrations has also been found . ;

Study Design

Related Conditions & MeSH terms

PCOS

Clinical Trial Details

NCT number	NCT03436108
Study type	Observational [Patient Registry]
Source	Aljazeera Hospital
Contact
Status	Completed
Phase
Start date	February 10, 2019
Completion date	January 20, 2020

View Details

See also
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