PCOS Clinical Trial
Official title:
High Response Predictive Parameters After Controlled Ovarian Stimulation in Women Undergoing Assisted Reproductive Techniques
Polycystic ovarian syndrome (PCOS) patients have an increased risk of ovarian
hyperstimulation syndrome (OHSS) after assisted reproduction techniques (ART). In addition,
these women have a high risk of develop further metabolic disorders. Rotterdam criteria
defined by the European Society of Human Reproduction and Endocrinology (ESHRE) are used for
the diagnosis of PCOS.
The aim of this study is both to determine the prevalence of PCOS in infertile patients who
require ART in our Center and to evaluate the usefulness of each specific diagnosis
criterium within Rotterdam criteria of PCOS as predictor of risk of OHSS. It also seeks to
establish a cohort of patients identified according to specific Rotterdam criteria of PCOS
to assess the incidence of long term complications.
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women. It affects
10 % of patients who undergo assisted reproductive techniques (ART). Rotterdam criteria
defined by the European Society of Human Reproduction and Endocrinology (ESHRE) are used for
the diagnosis of PCOS. According to such criteria, PCOS affects 5-10% of women of
reproductive age.
Patients with PCOS according to the Rotterdam criteria, as well as those with polycystic
ovaries by ultrasound, have a high risk of an exaggerated response to ovulation induction
therapy. Complications of the ovarian hyperstimulation syndrome (OHSS) include
hemoconcentration, thromboembolic disorders, electrolyte disorders, ascites, hydrothorax,
ovarian torsion, respiratory failure, liver failure, kidney failure or even death.
There is a lack of reliable markers that indicate risk of OHSS. It is also unknown whether
any specific criteria proposed in the Rotterdam consensus is more important than another or
independently influence on the results of the ARTs.
The aim of this study is both to determine the prevalence of PCOS in infertile patients who
require ART in our Center and to evaluate the usefulness of each specific diagnosis criteria
of PCOS as predictor of risk of OHSS. It also seeks to establish a cohort of patients
identified according to specific Rotterdam criteria of PCOS to assess the incidence of long
term complications.
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Observational Model: Case-Only, Time Perspective: Prospective
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